Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis

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dc.contributor.advisorJackson, Graham Ellisen_ZA
dc.contributor.authorMhlambiso, Zizileen_ZA
dc.date.accessioned2014-11-05T17:41:58Z
dc.date.available2014-11-05T17:41:58Z
dc.date.issued2009en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractIt has been shown that copper complexes are able to alleviate inflammation associated with Rheumatoid Arthritis (RA). Serum copper levels are elevated in RA and it has been postulated that endogenous copper might have a protective function in chronic inflammatory conditions. In designing Cu(I1) anti-inflammatory drugs, one needs to know the stability constants of the ligand together with Cu(I1) and the competitive metal ions, Zn(I1) and Ca(I1) in blood plasma. For this purpose glass electrode potentiometry, infrared (lR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, UV/Visible spectroscopy as well as blood plasma modelling were used to explore the coordination chemistry of a newly designed ligand, PCUL (Bis-(3- aminoethy-2-aminomethylpyridine )-oxahexacyclo-dodecane). PCUL protonation and formation constants with Cu(I1) and Zn(I1) were investigated by potentiometric analysis at 2SoC and 0.ISmol/dm3 Na + (CI) The potentiometric analysis showed that CU(I1) formed far more stable complexes at physiological pH with PCUL than the in vivo competitor Zn(I1). In this study the IR spectroscopic analysis was used to determine the Cu(I1)-PCUL complexation sequence. The IR spectra show that the central amines are coordinated to the metal ion first. The small frequency shift between pH 4.02 to 6.91 proves that the pyridyl nitrogen atoms are also coordinated to CU(I1).en_ZA
dc.identifier.apacitationMhlambiso, Z. (2009). <i>Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9280en_ZA
dc.identifier.chicagocitationMhlambiso, Zizile. <i>"Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009. http://hdl.handle.net/11427/9280en_ZA
dc.identifier.citationMhlambiso, Z. 2009. Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mhlambiso, Zizile AB - It has been shown that copper complexes are able to alleviate inflammation associated with Rheumatoid Arthritis (RA). Serum copper levels are elevated in RA and it has been postulated that endogenous copper might have a protective function in chronic inflammatory conditions. In designing Cu(I1) anti-inflammatory drugs, one needs to know the stability constants of the ligand together with Cu(I1) and the competitive metal ions, Zn(I1) and Ca(I1) in blood plasma. For this purpose glass electrode potentiometry, infrared (lR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, UV/Visible spectroscopy as well as blood plasma modelling were used to explore the coordination chemistry of a newly designed ligand, PCUL (Bis-(3- aminoethy-2-aminomethylpyridine )-oxahexacyclo-dodecane). PCUL protonation and formation constants with Cu(I1) and Zn(I1) were investigated by potentiometric analysis at 2SoC and 0.ISmol/dm3 Na + (CI) The potentiometric analysis showed that CU(I1) formed far more stable complexes at physiological pH with PCUL than the in vivo competitor Zn(I1). In this study the IR spectroscopic analysis was used to determine the Cu(I1)-PCUL complexation sequence. The IR spectra show that the central amines are coordinated to the metal ion first. The small frequency shift between pH 4.02 to 6.91 proves that the pyridyl nitrogen atoms are also coordinated to CU(I1). DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis TI - Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis UR - http://hdl.handle.net/11427/9280 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9280
dc.identifier.vancouvercitationMhlambiso Z. Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9280en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleDesign of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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