Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis

Simple item page
dc.contributor.authorOkpechi, Ikechi Gen_ZA
dc.contributor.authorAmeh, Oluwatoyin Ien_ZA
dc.contributor.authorBello, Aminu Ken_ZA
dc.contributor.authorRonco, Pierreen_ZA
dc.contributor.authorSwanepoel, Charles Ren_ZA
dc.contributor.authorKengne, Andre Pen_ZA
dc.date.accessioned2016-04-13T12:35:21Z
dc.date.available2016-04-13T12:35:21Z
dc.date.issued2016en_ZA
dc.description.abstractBackground and aim: Glomerulonephritis (GN) is a leading cause of end-stage renal disease (ESRD) in Africa. Data on epidemiology and outcomes of glomerular diseases from Africa is still limited. We conducted a systematic review on the epidemiology of histologically proven glomerular diseases in Africa between 1980 and 2014. Materials and methods We searched literature using PubMed, AfricaWide, the Cumulative Index to Nursing and Allied Health Literature on EBSCO Host, Scopus, African Journals online databases, and the African Index Medicus, for relevant studies. The review was conducted using standard methods and frameworks using only biopsy-confirmed data. RESULTS: Twenty four (24) studies comprising 12,093 reported biopsies from 13 countries were included in this analysis. The median number of biopsies per study was 127.0 (50-4436), most of the studies (70.0%) originated from North Africa and the number of performed kidney biopsies varied from 5.2 to 617 biopsies/year. Nephrotic syndrome was the commonest indication of renal biopsy. The frequency of reported primary pathologic patterns included, minimal change disease (MCD); 16.5% (95%CI: 11.2-22.6), focal segmental glomerulosclerosis (FSGS); 15.9% (11.3-21.1), mesangiocapillary GN (MCGN); 11.8% (9.2-14.6), crescentic GN; 2.0% (0.9-3.5) and IgA nephropathy 2.8% (1.3-4.9). Glomerular diseases related to hepatitis B and systemic lupus erythematosus had the highest prevalence among assessed secondary diseases: 8.4% (2.0-18.4) and 7.7% (4.5-11.7) respectively. There was no evidence of publication bias and regional differences were seen mostly for secondary GNs. CONCLUSIONS: Glomerular diseases remain poorly characterized in sub-Saharan Africa due to declining renal biopsy rates and consequent paucity of data on pathologic patterns of key renal diseases. Development of renal biopsy registries in Africa is likely to enable adequate characterization of the prevalence and patterns of glomerular diseases; this could have a positive impact on chronic kidney disease evaluation and treatment in the African continent since most glomerulopathies are amenable to treatment.en_ZA
dc.identifier.apacitationOkpechi, I. G., Ameh, O. I., Bello, A. K., Ronco, P., Swanepoel, C. R., & Kengne, A. P. (2016). Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis. <i>PLoS One</i>, http://hdl.handle.net/11427/18852en_ZA
dc.identifier.chicagocitationOkpechi, Ikechi G, Oluwatoyin I Ameh, Aminu K Bello, Pierre Ronco, Charles R Swanepoel, and Andre P Kengne "Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/18852en_ZA
dc.identifier.citationOkpechi, I. G., Ameh, O. I., Bello, A. K., Ronco, P., Swanepoel, C. R., & Kengne, A. P. (2016). Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis. PloS one, 11(3), e0152203. doi:10.1371/journal.pone.0152203en_ZA
dc.identifier.ris TY - Journal Article AU - Okpechi, Ikechi G AU - Ameh, Oluwatoyin I AU - Bello, Aminu K AU - Ronco, Pierre AU - Swanepoel, Charles R AU - Kengne, Andre P AB - Background and aim: Glomerulonephritis (GN) is a leading cause of end-stage renal disease (ESRD) in Africa. Data on epidemiology and outcomes of glomerular diseases from Africa is still limited. We conducted a systematic review on the epidemiology of histologically proven glomerular diseases in Africa between 1980 and 2014. Materials and methods We searched literature using PubMed, AfricaWide, the Cumulative Index to Nursing and Allied Health Literature on EBSCO Host, Scopus, African Journals online databases, and the African Index Medicus, for relevant studies. The review was conducted using standard methods and frameworks using only biopsy-confirmed data. RESULTS: Twenty four (24) studies comprising 12,093 reported biopsies from 13 countries were included in this analysis. The median number of biopsies per study was 127.0 (50-4436), most of the studies (70.0%) originated from North Africa and the number of performed kidney biopsies varied from 5.2 to 617 biopsies/year. Nephrotic syndrome was the commonest indication of renal biopsy. The frequency of reported primary pathologic patterns included, minimal change disease (MCD); 16.5% (95%CI: 11.2-22.6), focal segmental glomerulosclerosis (FSGS); 15.9% (11.3-21.1), mesangiocapillary GN (MCGN); 11.8% (9.2-14.6), crescentic GN; 2.0% (0.9-3.5) and IgA nephropathy 2.8% (1.3-4.9). Glomerular diseases related to hepatitis B and systemic lupus erythematosus had the highest prevalence among assessed secondary diseases: 8.4% (2.0-18.4) and 7.7% (4.5-11.7) respectively. There was no evidence of publication bias and regional differences were seen mostly for secondary GNs. CONCLUSIONS: Glomerular diseases remain poorly characterized in sub-Saharan Africa due to declining renal biopsy rates and consequent paucity of data on pathologic patterns of key renal diseases. Development of renal biopsy registries in Africa is likely to enable adequate characterization of the prevalence and patterns of glomerular diseases; this could have a positive impact on chronic kidney disease evaluation and treatment in the African continent since most glomerulopathies are amenable to treatment. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pone.0152203 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis TI - Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis UR - http://hdl.handle.net/11427/18852 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0152203en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18852
dc.identifier.vancouvercitationOkpechi IG, Ameh OI, Bello AK, Ronco P, Swanepoel CR, Kengne AP. Epidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysis. PLoS One. 2016; http://hdl.handle.net/11427/18852.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Nephrology and Hypertensionen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Okpechi et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherBiopsyen_ZA
dc.subject.otherAfricaen_ZA
dc.subject.otherAge groupsen_ZA
dc.subject.otherChronic kidney diseaseen_ZA
dc.subject.otherDatabase searchingen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherMeta-analysisen_ZA
dc.subject.otherPediatricsen_ZA
dc.titleEpidemiology of histologically proven Glomerulonephritis in Africa: A systematic review and meta-analysisen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Okpechi_Epidemiology_of_Histologically_2016.pdf
Size:
1.04 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles