New CO₂ chemistry for fine chemical synthesis

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dc.contributor.advisorHunter, Rogeren_ZA
dc.contributor.authorMsutu, Ath'enkosien_ZA
dc.date.accessioned2015-06-25T13:48:00Z
dc.date.available2015-06-25T13:48:00Z
dc.date.issued2011en_ZA
dc.descriptionIncludes abstract.~Includes bibliographical references (leaves 89-96).en_ZA
dc.description.abstractThere is a great need in the chemical industry for developing CO2 as a C1 building block as an important step towards "green chemistry". CO2 is also attractive as a chemical feedstock because it is readily available, inexpensive, nontoxic and it can replace toxic building blocks such as phosgene and CO. Industrially, megatons of CO2 are used each year for the production of urea, inorganic carbonates, salicylic acid, and polycarbonates, yet this is still miniscule compared to the immense potential that is still yet to be harnessed in using this versatile building block. This thesis discusses how a novel methodology was developed for synthesising a benzotriazole (Bt) urea directly from CO2 in a two-step, one-pot synthesis. The procedure involves trapping CO2 with a primary or secondary amine in the presence of DBU, and reaction of the resultant carbamate salt with triphenylphosphine and chlorobenzotriazole (BtCl) to produce Bt ureas in moderate to high yields. The Bt group may serve as a leaving group in nucleophilic substitution reactions, therefore it is also shown here how the Bt urea presents itself as a precursor for an array of useful organic intermediates. These intermediates include ureas, amides, S-thiocarbamates and sulfonylureas.en_ZA
dc.identifier.apacitationMsutu, A. (2011). <i>New CO₂ chemistry for fine chemical synthesis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/13102en_ZA
dc.identifier.chicagocitationMsutu, Ath'enkosi. <i>"New CO₂ chemistry for fine chemical synthesis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011. http://hdl.handle.net/11427/13102en_ZA
dc.identifier.citationMsutu, A. 2011. New CO₂ chemistry for fine chemical synthesis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Msutu, Ath'enkosi AB - There is a great need in the chemical industry for developing CO2 as a C1 building block as an important step towards "green chemistry". CO2 is also attractive as a chemical feedstock because it is readily available, inexpensive, nontoxic and it can replace toxic building blocks such as phosgene and CO. Industrially, megatons of CO2 are used each year for the production of urea, inorganic carbonates, salicylic acid, and polycarbonates, yet this is still miniscule compared to the immense potential that is still yet to be harnessed in using this versatile building block. This thesis discusses how a novel methodology was developed for synthesising a benzotriazole (Bt) urea directly from CO2 in a two-step, one-pot synthesis. The procedure involves trapping CO2 with a primary or secondary amine in the presence of DBU, and reaction of the resultant carbamate salt with triphenylphosphine and chlorobenzotriazole (BtCl) to produce Bt ureas in moderate to high yields. The Bt group may serve as a leaving group in nucleophilic substitution reactions, therefore it is also shown here how the Bt urea presents itself as a precursor for an array of useful organic intermediates. These intermediates include ureas, amides, S-thiocarbamates and sulfonylureas. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - New CO₂ chemistry for fine chemical synthesis TI - New CO₂ chemistry for fine chemical synthesis UR - http://hdl.handle.net/11427/13102 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13102
dc.identifier.vancouvercitationMsutu A. New CO₂ chemistry for fine chemical synthesis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13102en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleNew CO₂ chemistry for fine chemical synthesisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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