Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study

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dc.contributor.authorNtusi, Ntobekoen_ZA
dc.contributor.authorSever, Emilyen_ZA
dc.contributor.authorLockey, Josephen_ZA
dc.contributor.authorFrancis, Janeen_ZA
dc.contributor.authorPiechnik, Stefanen_ZA
dc.contributor.authorFerreira, Vanessaen_ZA
dc.contributor.authorMatthews, Paulen_ZA
dc.contributor.authorWordsworth, Paulen_ZA
dc.contributor.authorNeubauer, Stefanen_ZA
dc.contributor.authorKaramitsos, Theodorosen_ZA
dc.date.accessioned2015-12-07T08:47:09Z
dc.date.available2015-12-07T08:47:09Z
dc.date.issued2015en_ZA
dc.description.abstractSystemic sclerosis (SSc) is characterised by vascular dysfunction and multi-organ fibrosis, with the heart commonly involved. Cardiovascular disease (CVD) in SSc may be direct or indirect, but often remains subclinical. SSc patients with apparent cardiovascular clinical features are at greater risk of deterioration and premature cardiovascular death, often from complications of myocardial ischaemia. CMR first-pass perfusion detects myocardial ischaemia with great accuracy. We hypothesised that CMR first-pass perfusion would be able to differentiate between segmental (indicating epicardial coronary artery disease) and non-segmental subendocardial (indicating microvascular dysfunction) perfusion defects in patients with SSc; and that microvascular dysfunction (relating to chronic myocardial inflammation) was more frequent in SSc.en_ZA
dc.identifier.apacitationNtusi, N., Sever, E., Lockey, J., Francis, J., Piechnik, S., Ferreira, V., ... Karamitsos, T. (2015). Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study. <i>Journal of Cardiovascular Magnetic Resonance</i>, http://hdl.handle.net/11427/15630en_ZA
dc.identifier.chicagocitationNtusi, Ntobeko, Emily Sever, Joseph Lockey, Jane Francis, Stefan Piechnik, Vanessa Ferreira, Paul Matthews, Paul Wordsworth, Stefan Neubauer, and Theodoros Karamitsos "Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study." <i>Journal of Cardiovascular Magnetic Resonance</i> (2015) http://hdl.handle.net/11427/15630en_ZA
dc.identifier.citationNtusi, N. A., Sever, E., Lockey, J., Francis, J. M., Piechnik, S. K., Ferreira, V.M., … & , Karamitsos, T. D. (2015). Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance, 17(Suppl 1), Q71.en_ZA
dc.identifier.ris TY - Journal Article AU - Ntusi, Ntobeko AU - Sever, Emily AU - Lockey, Joseph AU - Francis, Jane AU - Piechnik, Stefan AU - Ferreira, Vanessa AU - Matthews, Paul AU - Wordsworth, Paul AU - Neubauer, Stefan AU - Karamitsos, Theodoros AB - Systemic sclerosis (SSc) is characterised by vascular dysfunction and multi-organ fibrosis, with the heart commonly involved. Cardiovascular disease (CVD) in SSc may be direct or indirect, but often remains subclinical. SSc patients with apparent cardiovascular clinical features are at greater risk of deterioration and premature cardiovascular death, often from complications of myocardial ischaemia. CMR first-pass perfusion detects myocardial ischaemia with great accuracy. We hypothesised that CMR first-pass perfusion would be able to differentiate between segmental (indicating epicardial coronary artery disease) and non-segmental subendocardial (indicating microvascular dysfunction) perfusion defects in patients with SSc; and that microvascular dysfunction (relating to chronic myocardial inflammation) was more frequent in SSc. DA - 2015 DB - OpenUCT DO - 10.1186/1532-429X-17-S1-Q71 DP - University of Cape Town J1 - Journal of Cardiovascular Magnetic Resonance LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study TI - Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study UR - http://hdl.handle.net/11427/15630 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15630
dc.identifier.urihttp://dx.doi.org/10.1186/1532-429X-17-S1-Q71
dc.identifier.vancouvercitationNtusi N, Sever E, Lockey J, Francis J, Piechnik S, Ferreira V, et al. Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2015; http://hdl.handle.net/11427/15630.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Ntusi et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceJournal of Cardiovascular Magnetic Resonanceen_ZA
dc.source.urihttp://www.jcmr-online.com/en_ZA
dc.subject.otherSystemic sclerosis (SSc)en_ZA
dc.subject.othervascular dysfunctionen_ZA
dc.subject.othermulti-organ fibrosis,en_ZA
dc.titleImpaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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