Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes

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dc.contributor.advisorGammon, David Wen_ZA
dc.contributor.authorMuhunga, Denis Ngumbuen_ZA
dc.date.accessioned2015-02-06T11:28:20Z
dc.date.available2015-02-06T11:28:20Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (leaves 69-72).en_ZA
dc.description.abstractTuberculosis (TB) is one of the world's most deadly diseases and kills approximately 1.7 million people each year. The developing resistance of TB to the two most common anti-TB drugs (isoniazid and rifampicin) proves the urgency of the current situation. The MshB reducing agent exclusively in the actinomycetes is used as a model for the development of new anti-TB drugs. It was shown that the stereoselectivity synthesis of C-2 alkyl glucoside gave a key intermediate for the suitable synthesis of glycosyl donors. In addition, we achieved the preparation of D-inositol derivative chirally pure and having the hydroxyl at the 1-position. However, the attempted glycosylation reaction failed to give the desired product.en_ZA
dc.identifier.apacitationMuhunga, D. N. (2010). <i>Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12396en_ZA
dc.identifier.chicagocitationMuhunga, Denis Ngumbu. <i>"Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2010. http://hdl.handle.net/11427/12396en_ZA
dc.identifier.citationMuhunga, D. 2010. Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Muhunga, Denis Ngumbu AB - Tuberculosis (TB) is one of the world's most deadly diseases and kills approximately 1.7 million people each year. The developing resistance of TB to the two most common anti-TB drugs (isoniazid and rifampicin) proves the urgency of the current situation. The MshB reducing agent exclusively in the actinomycetes is used as a model for the development of new anti-TB drugs. It was shown that the stereoselectivity synthesis of C-2 alkyl glucoside gave a key intermediate for the suitable synthesis of glycosyl donors. In addition, we achieved the preparation of D-inositol derivative chirally pure and having the hydroxyl at the 1-position. However, the attempted glycosylation reaction failed to give the desired product. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes TI - Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes UR - http://hdl.handle.net/11427/12396 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12396
dc.identifier.vancouvercitationMuhunga DN. Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12396en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleStereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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