Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses

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dc.contributor.authorVAN WYK, W
dc.contributor.authorDent, D
dc.contributor.authorHACKING, E
dc.contributor.authorLEARMONTH, G
dc.contributor.authorKOTTLER, R
dc.contributor.authorGUDGEON, C
dc.contributor.authorTiltman, A
dc.date.accessioned2021-10-08T07:17:52Z
dc.date.available2021-10-08T07:17:52Z
dc.date.issued1995
dc.description.abstractWe examined the safety and utility of the combined assessment of aspiration cytology and mammography in 705 women who had clinically suspicious or malignant palpable breast masses. Histological assessment confirmed 176 benign and 529 malignant lesions. There were no incorrect (false positive) diagnoses made in the 176 benign masses when combined assessment was used (specificity 1,0; predictive value 0,86); in isolation, however, there was a false positive cytological diagnosis («papillary carcinoma») and 3 false positive mammographic diagnoses. Benign disease (false negative) was incorrectly diagnosed by combined assessment in 4 of the 529 malignant masses (sensitivity 0,99; predictive value 0,98): cytological diagnoses were of fat necrosis (2) and benign cells on cytospin (1) and aspiration biopsy (1); mammographic diagnoses were of benign disease (2) and normality (2). Indeterminate («atypical», «suspicious») diagnoses were problematic and frequent (overall 223 (31,6%), malignant masses 137 (25,9%), benign masses 86 (48,9%); cytology 117 (16,6%), mammography 141 (20%). Thus, with the combined assessment of mammography and cytology in clinically suspicious breast masses, a decisive diagnosis was made in about two-thirds of cases allowing the safe commencement of therapy; the balance of patients required cone or excision biopsy.
dc.identifier.apacitationVAN WYK, W., Dent, D., HACKING, E., LEARMONTH, G., KOTTLER, R., GUDGEON, C., & Tiltman, A. (1995). Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses. <i>South African Medical Journal</i>, 85(2), 81 - 94. http://hdl.handle.net/11427/34846en_ZA
dc.identifier.chicagocitationVAN WYK, W, D Dent, E HACKING, G LEARMONTH, R KOTTLER, C GUDGEON, and A Tiltman "Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses." <i>South African Medical Journal</i> 85, 2. (1995): 81 - 94. http://hdl.handle.net/11427/34846en_ZA
dc.identifier.citationVAN WYK, W., Dent, D., HACKING, E., LEARMONTH, G., KOTTLER, R., GUDGEON, C. & Tiltman, A. 1995. Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses. <i>South African Medical Journal.</i> 85(2):81 - 94. http://hdl.handle.net/11427/34846en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - VAN WYK, W AU - Dent, D AU - HACKING, E AU - LEARMONTH, G AU - KOTTLER, R AU - GUDGEON, C AU - Tiltman, A AB - We examined the safety and utility of the combined assessment of aspiration cytology and mammography in 705 women who had clinically suspicious or malignant palpable breast masses. Histological assessment confirmed 176 benign and 529 malignant lesions. There were no incorrect (false positive) diagnoses made in the 176 benign masses when combined assessment was used (specificity 1,0; predictive value 0,86); in isolation, however, there was a false positive cytological diagnosis («papillary carcinoma») and 3 false positive mammographic diagnoses. Benign disease (false negative) was incorrectly diagnosed by combined assessment in 4 of the 529 malignant masses (sensitivity 0,99; predictive value 0,98): cytological diagnoses were of fat necrosis (2) and benign cells on cytospin (1) and aspiration biopsy (1); mammographic diagnoses were of benign disease (2) and normality (2). Indeterminate («atypical», «suspicious») diagnoses were problematic and frequent (overall 223 (31,6%), malignant masses 137 (25,9%), benign masses 86 (48,9%); cytology 117 (16,6%), mammography 141 (20%). Thus, with the combined assessment of mammography and cytology in clinically suspicious breast masses, a decisive diagnosis was made in about two-thirds of cases allowing the safe commencement of therapy; the balance of patients required cone or excision biopsy. DA - 1995 DB - OpenUCT DP - University of Cape Town IS - 2 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 1995 SM - 0038-2469 T1 - Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses TI - Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses UR - http://hdl.handle.net/11427/34846 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34846
dc.identifier.vancouvercitationVAN WYK W, Dent D, HACKING E, LEARMONTH G, KOTTLER R, GUDGEON C, et al. Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses. South African Medical Journal. 1995;85(2):81 - 94. http://hdl.handle.net/11427/34846.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Surgery
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue2
dc.source.journalvolume85
dc.source.pagination81 - 94
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherTumor
dc.subject.otherMammary gland
dc.subject.otherExploration
dc.subject.otherAspiration punction
dc.subject.otherCytology
dc.subject.otherMammography
dc.subject.otherHuman
dc.subject.otherFemale
dc.subject.otherResult
dc.subject.otherSouth Africa
dc.subject.otherAfrica
dc.subject.otherTumeur
dc.subject.otherGlande mammaire
dc.subject.otherPonction aspiration
dc.subject.otherCytologie
dc.subject.otherMammographie
dc.subject.otherHomme
dc.subject.otherFemelle
dc.subject.otherRésultat
dc.subject.otherRépublique Sud Africaine
dc.subject.otherAfrique
dc.subject.otherGlándula mamaria
dc.subject.otherExploración
dc.titleCombined assessment (aspiration cytology and mammography) of clinically suspicious breast masses
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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