The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence

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dc.contributor.authorKenyon, Chris Richarden_ZA
dc.contributor.authorOsbak, Karaen_ZA
dc.contributor.authorTsoumanis, Achilleasen_ZA
dc.date.accessioned2016-10-31T07:38:09Z
dc.date.available2016-10-31T07:38:09Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary: Syphilis rates have varied tremendously between different populations around the world. We conducted a systematic review of syphilis prevalence in pregnant women in 13 populations with available data for the last 100 years. Our findings were that in most populations syphilis prevalence dropped to under 1% before 1960. In the 2 populations from sub Saharan Africa, the syphilis prevalence remained around 6% until 50 years after the introduction of penicillin. Other systematic reviews were utilized to provide syphilis prevalence estimates for all countries with available data for the periods 1990-1999 and 2008. We assessed if there was a correlation between national syphilis prevalence in these periods and five explanatory factors. Only residence in sub-Saharan Africa was associated with syphilis prevalence in both time periods. These findings, considered in conjunction with other types of evidence we review, such as the strong correlations at population level between syphilis prevalence and those of Herpes Simplex Virus-2 prevalence and HIV prevalence, suggest that common risk factors may underpin the spread of all three of these sexually transmitted diseases. Establishing what these factors are is of great importance to improve the health of highly affected populations such as those in sub-Saharan Africa.en_ZA
dc.identifier.apacitationKenyon, C. R., Osbak, K., & Tsoumanis, A. (2016). The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence. <i>PLOS Neglected Tropical Diseases</i>, http://hdl.handle.net/11427/22361en_ZA
dc.identifier.chicagocitationKenyon, Chris Richard, Kara Osbak, and Achilleas Tsoumanis "The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence." <i>PLOS Neglected Tropical Diseases</i> (2016) http://hdl.handle.net/11427/22361en_ZA
dc.identifier.citationKenyon, C. R., Osbak, K., & Tsoumanis, A. (2016). The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence. PLoS Negl Trop Dis, 10(5), e0004711. doi:10.1371/journal.pntd.0004711en_ZA
dc.identifier.ris TY - Journal Article AU - Kenyon, Chris Richard AU - Osbak, Kara AU - Tsoumanis, Achilleas AB - Author Summary: Syphilis rates have varied tremendously between different populations around the world. We conducted a systematic review of syphilis prevalence in pregnant women in 13 populations with available data for the last 100 years. Our findings were that in most populations syphilis prevalence dropped to under 1% before 1960. In the 2 populations from sub Saharan Africa, the syphilis prevalence remained around 6% until 50 years after the introduction of penicillin. Other systematic reviews were utilized to provide syphilis prevalence estimates for all countries with available data for the periods 1990-1999 and 2008. We assessed if there was a correlation between national syphilis prevalence in these periods and five explanatory factors. Only residence in sub-Saharan Africa was associated with syphilis prevalence in both time periods. These findings, considered in conjunction with other types of evidence we review, such as the strong correlations at population level between syphilis prevalence and those of Herpes Simplex Virus-2 prevalence and HIV prevalence, suggest that common risk factors may underpin the spread of all three of these sexually transmitted diseases. Establishing what these factors are is of great importance to improve the health of highly affected populations such as those in sub-Saharan Africa. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pntd.0004711 DP - University of Cape Town J1 - PLOS Neglected Tropical Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence TI - The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence UR - http://hdl.handle.net/11427/22361 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pntd.0004711en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22361
dc.identifier.vancouvercitationKenyon CR, Osbak K, Tsoumanis A. The global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalence. PLOS Neglected Tropical Diseases. 2016; http://hdl.handle.net/11427/22361.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Kenyon et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLOS Neglected Tropical Diseasesen_ZA
dc.source.urihttp://journals.plos.org/plosntdsen_ZA
dc.subject.otherSyphilisen_ZA
dc.subject.otherAfricaen_ZA
dc.subject.otherPregnancyen_ZA
dc.subject.otherGlobal healthen_ZA
dc.subject.otherPenicillinen_ZA
dc.subject.otherEnzyme-linked immunoassaysen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherNorwayen_ZA
dc.titleThe global epidemiology of syphilis in the past century - a systematic review based on antenatal syphilis prevalenceen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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