Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3
| dc.contributor.advisor | Brink, Anita | |
| dc.contributor.author | Hashlan, Mohammed Hussain | |
| dc.date.accessioned | 2023-03-13T11:54:36Z | |
| dc.date.available | 2023-03-13T11:54:36Z | |
| dc.date.issued | 2022 | |
| dc.date.updated | 2023-02-20T12:55:11Z | |
| dc.description.abstract | Objectives: One can assess cortical defects on the early images of [99mTc]Tc-MAG3 renography. We aim to assess interobserver and intraobserver reproducibility for detecting renal cortical defects using [ 99mTc]Tc-MAG3 for adults and children; identify causes for poor inter- and intraobserver reproducibility and to assess the effect of the kidney to background ratio (KTBR) on reproducibility. Methods: A 100 adult and 200 paediatric renograms were included. The observers reviewed the summed 1- min posterior images for the first four minutes to detect cortical defects. Interobserver reproducibility between three observers and intra-observer reproducibility for two observers were determined. Agreement was tested using percentage agreement, Krippendorff's reliability coefficient alpha and Cohen's kappa statistic. The association between KTBR and agreement was assessed. Results: Interobserver agreement on the 1-2 minute images was 78 (95% CI: 74.8 - 82.7%) and 79.7 (95% CI: 75.9 - 83.5%) for left and right kidneys respectively. Intraobserver percentage was 89.7% (95% CI: 86.2 - 93.1%) for the senior and 80.7% (95% CI: 76.2 - 85.2%) for the junior observer. In 13.5% (27) of the adult and 4.5% (19) of the paediatric kidneys the difference in image interpretation between the observers would have had a clinical impact. If the KTBR is ≤ 2, the percentage agreement was between 61.5% and 64.8%. In cases with a KTBR > 2, the percentage agreement was between 83.6% and 87.1%. Conclusion: The percentage interobserver agreement was moderate. Disagreement between normal and abnormal cases were infrequent. The interobserver reproducibility was decreased when the KTBR was ≤ 2. | |
| dc.identifier.apacitation | Hashlan, M. H. (2022). <i>Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3</i>. (). ,Faculty of Health Sciences ,Division of Radiology. Retrieved from http://hdl.handle.net/11427/37397 | en_ZA |
| dc.identifier.chicagocitation | Hashlan, Mohammed Hussain. <i>"Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3."</i> ., ,Faculty of Health Sciences ,Division of Radiology, 2022. http://hdl.handle.net/11427/37397 | en_ZA |
| dc.identifier.citation | Hashlan, M.H. 2022. Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3. . ,Faculty of Health Sciences ,Division of Radiology. http://hdl.handle.net/11427/37397 | en_ZA |
| dc.identifier.ris | TY - Master Thesis AU - Hashlan, Mohammed Hussain AB - Objectives: One can assess cortical defects on the early images of [99mTc]Tc-MAG3 renography. We aim to assess interobserver and intraobserver reproducibility for detecting renal cortical defects using [ 99mTc]Tc-MAG3 for adults and children; identify causes for poor inter- and intraobserver reproducibility and to assess the effect of the kidney to background ratio (KTBR) on reproducibility. Methods: A 100 adult and 200 paediatric renograms were included. The observers reviewed the summed 1- min posterior images for the first four minutes to detect cortical defects. Interobserver reproducibility between three observers and intra-observer reproducibility for two observers were determined. Agreement was tested using percentage agreement, Krippendorff's reliability coefficient alpha and Cohen's kappa statistic. The association between KTBR and agreement was assessed. Results: Interobserver agreement on the 1-2 minute images was 78 (95% CI: 74.8 - 82.7%) and 79.7 (95% CI: 75.9 - 83.5%) for left and right kidneys respectively. Intraobserver percentage was 89.7% (95% CI: 86.2 - 93.1%) for the senior and 80.7% (95% CI: 76.2 - 85.2%) for the junior observer. In 13.5% (27) of the adult and 4.5% (19) of the paediatric kidneys the difference in image interpretation between the observers would have had a clinical impact. If the KTBR is ≤ 2, the percentage agreement was between 61.5% and 64.8%. In cases with a KTBR > 2, the percentage agreement was between 83.6% and 87.1%. Conclusion: The percentage interobserver agreement was moderate. Disagreement between normal and abnormal cases were infrequent. The interobserver reproducibility was decreased when the KTBR was ≤ 2. DA - 2022_ DB - OpenUCT DP - University of Cape Town KW - Nuclear Medicine LK - https://open.uct.ac.za PY - 2022 T1 - Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 TI - Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 UR - http://hdl.handle.net/11427/37397 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/37397 | |
| dc.identifier.vancouvercitation | Hashlan MH. Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3. []. ,Faculty of Health Sciences ,Division of Radiology, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/37397 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Division of Radiology | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | Nuclear Medicine | |
| dc.title | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |