Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis

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dc.contributor.advisorEgan, Timothy Jen_ZA
dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorKuter, Daviden_ZA
dc.date.accessioned2014-11-11T12:58:14Z
dc.date.available2014-11-11T12:58:14Z
dc.date.issued2009en_ZA
dc.descriptionIncludes bibliographical references (leaves 116-122).en_ZA
dc.description.abstractInvestigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration.en_ZA
dc.identifier.apacitationKuter, D. (2009). <i>Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9562en_ZA
dc.identifier.chicagocitationKuter, David. <i>"Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009. http://hdl.handle.net/11427/9562en_ZA
dc.identifier.citationKuter, D. 2009. Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kuter, David AB - Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis TI - Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis UR - http://hdl.handle.net/11427/9562 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9562
dc.identifier.vancouvercitationKuter D. Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9562en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleTowards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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