Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits

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dc.contributor.authorCarter, R. Colin
dc.contributor.authorDodge, Neil C.
dc.contributor.authorMolteno, Christopher D.
dc.contributor.authorMeintjes, Ernesta M.
dc.contributor.authorJacobson, Joseph L.
dc.contributor.authorJacobson, Sandra W.
dc.date.accessioned2023-09-18T11:54:13Z
dc.date.available2023-09-18T11:54:13Z
dc.date.issued2022-10-21
dc.date.updated2022-10-26T11:08:21Z
dc.description.abstractWe have previously demonstrated prenatal alcohol exposure (PAE)-related alterations in maternal and infant iron homeostasis. Given that early iron deficiency and PAE both lead to growth restriction and deficits in recognition memory and processing speed, we hypothesized that PAE-related iron homeostasis alterations may mediate and/or moderate effects of PAE on growth and neurobehavior. We examined this hypothesis in a prenatally recruited, prospective longitudinal birth cohort [87 mother-infant pairs with heavy prenatal alcohol exposure (mean = 7.2 drinks/occasion on 1.4 days/week); 71 controls], with serial growth measures and infant neurobehavioral assessments. PAE was related to growth restriction at 2 weeks and 5 years, and, in infancy, poorer visual recognition memory, slower processing speed, lower complexity of symbolic play, and higher emotionality and shyness on a parental report temperament scale. Lower maternal hemoglobin-to-log(ferritin) ratio, which we have shown to be associated with PAE, appeared to exacerbate PAE-related 2-week head circumference reductions, and elevated maternal ferritin, which we have shown to be associated with PAE, appeared to exacerbate PAE-related visual recognition memory deficits. In causal inference analyses, PAE-related elevations in maternal ferritin and hemoglobin:log(ferritin) appeared to statistically mediate 22.6–82.3% of PAE-related growth restriction. These findings support potential mechanistic roles of iron homeostasis alterations in fetal alcohol spectrum disorders (FASD).
dc.identifierdoi: 10.3390/nu14204432
dc.identifier.apacitationCarter, R. Colin., Dodge, Neil C., Molteno, Christopher D., Meintjes, Ernesta M., Jacobson, Joseph L., & Jacobson, Sandra W. (2022). Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits. <i>Nutrients</i>, 14(20), 4432. http://hdl.handle.net/11427/38736en_ZA
dc.identifier.chicagocitationCarter, R. Colin, Neil C. Dodge, Christopher D. Molteno, Ernesta M. Meintjes, Joseph L. Jacobson, and Sandra W. Jacobson "Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits." <i>Nutrients</i> 14, 20. (2022): 4432. http://hdl.handle.net/11427/38736en_ZA
dc.identifier.citationCarter, R. Colin., Dodge, Neil C., Molteno, Christopher D., Meintjes, Ernesta M., Jacobson, Joseph L. & Jacobson, Sandra W. 2022. Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits. <i>Nutrients.</i> 14(20):4432. http://hdl.handle.net/11427/38736en_ZA
dc.identifier.ris TY - Journal Article AU - Carter, R. Colin AU - Dodge, Neil C. AU - Molteno, Christopher D. AU - Meintjes, Ernesta M. AU - Jacobson, Joseph L. AU - Jacobson, Sandra W. AB - We have previously demonstrated prenatal alcohol exposure (PAE)-related alterations in maternal and infant iron homeostasis. Given that early iron deficiency and PAE both lead to growth restriction and deficits in recognition memory and processing speed, we hypothesized that PAE-related iron homeostasis alterations may mediate and/or moderate effects of PAE on growth and neurobehavior. We examined this hypothesis in a prenatally recruited, prospective longitudinal birth cohort [87 mother-infant pairs with heavy prenatal alcohol exposure (mean = 7.2 drinks/occasion on 1.4 days/week); 71 controls], with serial growth measures and infant neurobehavioral assessments. PAE was related to growth restriction at 2 weeks and 5 years, and, in infancy, poorer visual recognition memory, slower processing speed, lower complexity of symbolic play, and higher emotionality and shyness on a parental report temperament scale. Lower maternal hemoglobin-to-log(ferritin) ratio, which we have shown to be associated with PAE, appeared to exacerbate PAE-related 2-week head circumference reductions, and elevated maternal ferritin, which we have shown to be associated with PAE, appeared to exacerbate PAE-related visual recognition memory deficits. In causal inference analyses, PAE-related elevations in maternal ferritin and hemoglobin:log(ferritin) appeared to statistically mediate 22.6&ndash;82.3% of PAE-related growth restriction. These findings support potential mechanistic roles of iron homeostasis alterations in fetal alcohol spectrum disorders (FASD). DA - 2022-10-21 DB - OpenUCT DP - University of Cape Town IS - 20 J1 - Nutrients LK - https://open.uct.ac.za PY - 2022 T1 - Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits TI - Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits UR - http://hdl.handle.net/11427/38736 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/38736
dc.identifier.vancouvercitationCarter R Colin, Dodge Neil C, Molteno Christopher D, Meintjes Ernesta M, Jacobson Joseph L, Jacobson Sandra W. Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits. Nutrients. 2022;14(20):4432. http://hdl.handle.net/11427/38736.en_ZA
dc.publisherMultidisciplinary Digital Publishing Institute
dc.publisher.departmentHuman Biology
dc.publisher.departmentPsychiatry and Mental Health
dc.publisher.facultyHealth Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceNutrients
dc.source.journalissue20
dc.source.journalvolume14
dc.source.pagination4432
dc.source.urihttps://www.mdpi.com/journal/nutrients
dc.titleMediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits
dc.typeJournal Article
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