HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study

Simple item page
dc.contributor.authorNtsekhe, Mpikoen_ZA
dc.contributor.authorWiysonge, Charles Sen_ZA
dc.contributor.authorGumedze, Freedomen_ZA
dc.contributor.authorMaartens, Garyen_ZA
dc.contributor.authorCommerford, Patrick Jen_ZA
dc.contributor.authorVolmink, Jimmy Aen_ZA
dc.contributor.authorMayosi, Bongani Men_ZA
dc.date.accessioned2015-11-23T12:36:55Z
dc.date.available2015-11-23T12:36:55Z
dc.date.issued2008en_ZA
dc.description.abstractBACKGROUND: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown. Methods and RESULTS: We conducted a prospective observational study to determine the association between HIV infection and the incidence of constrictive pericarditis among 185 patients (median age 33 years) with suspected tuberculous pericardial effusion. These patients were recruited consecutively between March and October 2004 on commencement of anti-tuberculosis treatment, from 15 hospitals in Cameroon, Nigeria and South Africa. Surviving patients (N = 119) were assessed for clinical evidence of constrictive pericarditis at 3 and 6 months of follow-up. Clinical features of HIV infection were present in 42 (35.2%) of the 119 patients at enrolment into the study. 66 of the 119 (56.9%) patients consented to HIV testing at enrolment. During the 6 months of follow-up, a clinical diagnosis of constrictive pericarditis was made in 13 of the 119 patients (10.9 %, 95% confidence interval [CI] 5.9-18%). Patients with clinical features of HIV infection appear less likely to develop constriction than those without (4.8% versus 14.3%; P = 0.08). None of the 33 HIV seropositive patients developed constriction, but 8 (24.2%, 95%CI 11.1-42.3%) of the 33 HIV seronegative patients did (P = 0.005). In a multivariate logistic regression model adjusting simultaneously for several baseline characteristics, only clinical signs of HIV infection were significantly associated with a lower risk of constriction (odd ratio 0.14, 95% CI 0.02-0.87, P = 0.035). CONCLUSIONS: These data suggest that HIV infection is associated with a lower incidence of pericardial constriction in patients with presumed tuberculous pericarditis.en_ZA
dc.identifier.apacitationNtsekhe, M., Wiysonge, C. S., Gumedze, F., Maartens, G., Commerford, P. J., Volmink, J. A., & Mayosi, B. M. (2008). HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study. <i>PLoS One</i>, http://hdl.handle.net/11427/15345en_ZA
dc.identifier.chicagocitationNtsekhe, Mpiko, Charles S Wiysonge, Freedom Gumedze, Gary Maartens, Patrick J Commerford, Jimmy A Volmink, and Bongani M Mayosi "HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/15345en_ZA
dc.identifier.citationNtsekhe, M., Wiysonge, C. S., Gumedze, F., Maartens, G., Commerford, P. J., Volmink, J. A., & Mayosi, B. M. (2008). HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study. PLoS One, 3(6), e2253. doi:10.1371/journal.pone.0002253en_ZA
dc.identifier.ris TY - Journal Article AU - Ntsekhe, Mpiko AU - Wiysonge, Charles S AU - Gumedze, Freedom AU - Maartens, Gary AU - Commerford, Patrick J AU - Volmink, Jimmy A AU - Mayosi, Bongani M AB - BACKGROUND: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection on the incidence of constrictive pericarditis following tuberculous pericardial effusion is unknown. Methods and RESULTS: We conducted a prospective observational study to determine the association between HIV infection and the incidence of constrictive pericarditis among 185 patients (median age 33 years) with suspected tuberculous pericardial effusion. These patients were recruited consecutively between March and October 2004 on commencement of anti-tuberculosis treatment, from 15 hospitals in Cameroon, Nigeria and South Africa. Surviving patients (N = 119) were assessed for clinical evidence of constrictive pericarditis at 3 and 6 months of follow-up. Clinical features of HIV infection were present in 42 (35.2%) of the 119 patients at enrolment into the study. 66 of the 119 (56.9%) patients consented to HIV testing at enrolment. During the 6 months of follow-up, a clinical diagnosis of constrictive pericarditis was made in 13 of the 119 patients (10.9 %, 95% confidence interval [CI] 5.9-18%). Patients with clinical features of HIV infection appear less likely to develop constriction than those without (4.8% versus 14.3%; P = 0.08). None of the 33 HIV seropositive patients developed constriction, but 8 (24.2%, 95%CI 11.1-42.3%) of the 33 HIV seronegative patients did (P = 0.005). In a multivariate logistic regression model adjusting simultaneously for several baseline characteristics, only clinical signs of HIV infection were significantly associated with a lower risk of constriction (odd ratio 0.14, 95% CI 0.02-0.87, P = 0.035). CONCLUSIONS: These data suggest that HIV infection is associated with a lower incidence of pericardial constriction in patients with presumed tuberculous pericarditis. DA - 2008 DB - OpenUCT DO - 10.1371/journal.pone.0002253 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study TI - HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study UR - http://hdl.handle.net/11427/15345 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15345
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0002253
dc.identifier.vancouvercitationNtsekhe M, Wiysonge CS, Gumedze F, Maartens G, Commerford PJ, Volmink JA, et al. HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study. PLoS One. 2008; http://hdl.handle.net/11427/15345.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2008 Ntsekhe et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHIV infectionsen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherFibrosisen_ZA
dc.subject.otherObservational studiesen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherHIV epidemiologyen_ZA
dc.subject.otherAfricaen_ZA
dc.subject.otherChemotherapyen_ZA
dc.titleHIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ntsekhe_HIV_Infection_2008.pdf
Size:
127.22 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles