Use of phenobarbitone for treating childhood epilepsy in resource-poor countries

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dc.contributor.authorWilmshurst, Jo M
dc.contributor.authorVan Toorn, Ronald
dc.date.accessioned2016-01-18T08:11:02Z
dc.date.available2016-01-18T08:11:02Z
dc.date.issued2005
dc.date.updated2016-01-18T08:02:33Z
dc.description.abstractShould the continued use of phenobarbitone for childhood epilepsy in resource-poor countries be considered a form of discrimination? Phenobarbitone was recommended by the World Health Organization (WHO) as the first-line agent for the control of seizures,1 but this has been contested on the grounds that it is biased against resource-poor countries.2 It was first used as an anticonvulsant in 1912, but now has little role to play in First-World countries where the newer generation agents are readily accessible. Phenobarbitone monotherapy has equivalent efficacy to the newer anticonvulsants (phenytoin, sodium valproate and carbamazepine) in children with partial-onset and generalised tonic-clonic seizures.3 Phenobarbitone is cheap, readily available, and easy to use and store. However, it has definite cognitive and behavioural side-effects in many children. It can exacerbate seizures in about 35% of children, and extreme caution should be taken with children who have a pre-morbid state of behavioural problems or attention deficit hyperactivity disorder (ADHD).en_ZA
dc.identifier.apacitationWilmshurst, J. M., & Van Toorn, R. (2005). Use of phenobarbitone for treating childhood epilepsy in resource-poor countries. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/16411en_ZA
dc.identifier.chicagocitationWilmshurst, Jo M, and Ronald Van Toorn "Use of phenobarbitone for treating childhood epilepsy in resource-poor countries." <i>South African Medical Journal</i> (2005) http://hdl.handle.net/11427/16411en_ZA
dc.identifier.citationWilmshurst, J. M., & Van Toorn, R. (2005). Use of phenobarbitone for treating childhood epilepsy in resource-poor countries: issues in medicine: SAMJ forum. South African Medical Journal, 95(6), 392.en_ZA
dc.identifier.issn0256-9574en_ZA
dc.identifier.ris TY - Journal Article AU - Wilmshurst, Jo M AU - Van Toorn, Ronald AB - Should the continued use of phenobarbitone for childhood epilepsy in resource-poor countries be considered a form of discrimination? Phenobarbitone was recommended by the World Health Organization (WHO) as the first-line agent for the control of seizures,1 but this has been contested on the grounds that it is biased against resource-poor countries.2 It was first used as an anticonvulsant in 1912, but now has little role to play in First-World countries where the newer generation agents are readily accessible. Phenobarbitone monotherapy has equivalent efficacy to the newer anticonvulsants (phenytoin, sodium valproate and carbamazepine) in children with partial-onset and generalised tonic-clonic seizures.3 Phenobarbitone is cheap, readily available, and easy to use and store. However, it has definite cognitive and behavioural side-effects in many children. It can exacerbate seizures in about 35% of children, and extreme caution should be taken with children who have a pre-morbid state of behavioural problems or attention deficit hyperactivity disorder (ADHD). DA - 2005 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 SM - 0256-9574 T1 - Use of phenobarbitone for treating childhood epilepsy in resource-poor countries TI - Use of phenobarbitone for treating childhood epilepsy in resource-poor countries UR - http://hdl.handle.net/11427/16411 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16411
dc.identifier.vancouvercitationWilmshurst JM, Van Toorn R. Use of phenobarbitone for treating childhood epilepsy in resource-poor countries. South African Medical Journal. 2005; http://hdl.handle.net/11427/16411.en_ZA
dc.languageengen_ZA
dc.publisherSouth African Medical Journalen_ZA
dc.publisher.departmentDivision of Neurologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution - NonCommercial Works License*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_ZA
dc.sourceSouth African Medical Journalen_ZA
dc.source.urihttp://www.samj.org.za
dc.titleUse of phenobarbitone for treating childhood epilepsy in resource-poor countriesen_ZA
dc.typeJournal Articleen_ZA
uct.subject.keywordsphenobarbitoneen_ZA
uct.subject.keywordschildhood epilepsyen_ZA
uct.subject.keywordsresource-poor countriesen_ZA
uct.type.filetypeText
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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