DNA-mediated biomineralization of a new planar Pt-complex
| dc.contributor.author | Klump, H H | |
| dc.contributor.author | Koch, K | |
| dc.contributor.author | Lin, C T | |
| dc.date.accessioned | 2017-04-05T10:42:14Z | |
| dc.date.available | 2017-04-05T10:42:14Z | |
| dc.date.issued | 2006 | |
| dc.date.updated | 2016-01-13T08:25:06Z | |
| dc.description.abstract | The crystal growth morphology of a coordination complex of Pt(II) that crystallizes from solution can be controlled by using a second molecular species such as peptides or other organic compounds. Examples of crystal growth controlled by nucleic acids are few. In this article we describe the use of branched three-way junction (3WJ) DNA to influence the crystal growth of a planar platinum compound, cis-[(2, 2′-bipyridyl)N,N-di(2-hydroxyethyl)-N′-benzoylthioureatoplatinum(II)]chloride. Platinum complexes with extended planar aromatic residues are capable of stacking in the absence as well as in the presence of linear DNA double helices. This feature is based on the interaction of the compound with DNA through intercalation, resulting in the prevention of binding of DNA polymerase. Microscopic one-dimensional crystals were observed under these conditions. In the presence of the branched 3WJ DNA, however, additional nucleation sites are present, resulting in extended crystal growth of unique Pt compounds. At least two different crystal modifications were observed using transmission electron microscopy. | |
| dc.identifier.apacitation | Klump, H. H., Koch, K., & Lin, C. T. (2006). DNA-mediated biomineralization of a new planar Pt-complex. <i>South African Journal of Science</i>, http://hdl.handle.net/11427/24164 | en_ZA |
| dc.identifier.chicagocitation | Klump, H H, K Koch, and C T Lin "DNA-mediated biomineralization of a new planar Pt-complex." <i>South African Journal of Science</i> (2006) http://hdl.handle.net/11427/24164 | en_ZA |
| dc.identifier.citation | Klump, H. H., Koch, K., & Lin, C. T. (2006). DNA-mediated biomineralization of a new planar Pt-complex. South African Journal Of Science, 102(5/6), 264-266. | |
| dc.identifier.ris | TY - Journal Article AU - Klump, H H AU - Koch, K AU - Lin, C T AB - The crystal growth morphology of a coordination complex of Pt(II) that crystallizes from solution can be controlled by using a second molecular species such as peptides or other organic compounds. Examples of crystal growth controlled by nucleic acids are few. In this article we describe the use of branched three-way junction (3WJ) DNA to influence the crystal growth of a planar platinum compound, cis-[(2, 2′-bipyridyl)N,N-di(2-hydroxyethyl)-N′-benzoylthioureatoplatinum(II)]chloride. Platinum complexes with extended planar aromatic residues are capable of stacking in the absence as well as in the presence of linear DNA double helices. This feature is based on the interaction of the compound with DNA through intercalation, resulting in the prevention of binding of DNA polymerase. Microscopic one-dimensional crystals were observed under these conditions. In the presence of the branched 3WJ DNA, however, additional nucleation sites are present, resulting in extended crystal growth of unique Pt compounds. At least two different crystal modifications were observed using transmission electron microscopy. DA - 2006 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Science LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - DNA-mediated biomineralization of a new planar Pt-complex TI - DNA-mediated biomineralization of a new planar Pt-complex UR - http://hdl.handle.net/11427/24164 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/24164 | |
| dc.identifier.vancouvercitation | Klump HH, Koch K, Lin CT. DNA-mediated biomineralization of a new planar Pt-complex. South African Journal of Science. 2006; http://hdl.handle.net/11427/24164. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Department of Molecular and Cell Biology | en_ZA |
| dc.publisher.faculty | Faculty of Science | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Journal of Science | |
| dc.source.uri | http://www.sajs.co.za/ | |
| dc.subject.other | Biomineralization | |
| dc.subject.other | DNA | |
| dc.subject.other | Peptides | |
| dc.subject.other | Nucleic acids | |
| dc.subject.other | Organic compounds | |
| dc.subject.other | DNA polymerases | |
| dc.subject.other | Clathrate compounds | |
| dc.subject.other | Transmission electron microscopy | |
| dc.subject.other | Platinum | |
| dc.title | DNA-mediated biomineralization of a new planar Pt-complex | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |