Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study

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dc.contributor.authorHainline, Clotildeen_ZA
dc.contributor.authorTaliep, Reghanaen_ZA
dc.contributor.authorSorour, Gillen_ZA
dc.contributor.authorNachman, Sharonen_ZA
dc.contributor.authorRabie, Helenaen_ZA
dc.contributor.authorDobbels, Elsen_ZA
dc.contributor.authorvan Rensburg, Anitaen_ZA
dc.contributor.authorCornell, Mornaen_ZA
dc.contributor.authorViolari, Avyen_ZA
dc.contributor.authorMadhi, Shabiren_ZA
dc.contributor.authorCotton, Marken_ZA
dc.date.accessioned2015-11-11T12:04:19Z
dc.date.available2015-11-11T12:04:19Z
dc.date.issued2011en_ZA
dc.description.abstractBACKGROUND: Although otorrhea occurs commonly in HIV-infected infants, there are few data. We compared the incidence of otorrhea in infants receiving early vs deferred ART in the Children with HIV Early Antiretroviral (CHER) trial. Infants aged 6 to 12 weeks of age with confirmed HIV infection and a CD4 percentage greater than or equal to 25% were randomized to early or deferred ART at two sites in South Africa. Medical records from one study site were reviewed for otorrhea.FINDINGS:Data were reviewed from the start of the trial in July 2005 until 20 June 2007, when the Data Safety Monitoring Board recommended that randomization to the deferred arm should stop and that all infants in this arm be reviewed for commencing antiretroviral therapy. Infants entered the study at a median of 7.4 weeks of age. Eleven of 38 (29%) on deferred therapy and 7 of 75 (9%) in the early-therapy group developed otorrhea (risk ratio 3.1, 95% confidence interval (CI) 1.31-7.36; p = 0.01). CONCLUSIONS: Early initiation of antiretroviral therapy is associated with significantly less otorrhea than when a deferred strategy is followed.TRIAL REGISTRATION:NCT00102960. ClinicalTrials.Goven_ZA
dc.identifier.apacitationHainline, C., Taliep, R., Sorour, G., Nachman, S., Rabie, H., Dobbels, E., ... Cotton, M. (2011). Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study. <i>BMC Research Notes</i>, http://hdl.handle.net/11427/14910en_ZA
dc.identifier.chicagocitationHainline, Clotilde, Reghana Taliep, Gill Sorour, Sharon Nachman, Helena Rabie, Els Dobbels, Anita van Rensburg, et al "Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study." <i>BMC Research Notes</i> (2011) http://hdl.handle.net/11427/14910en_ZA
dc.identifier.citationHainline, C., Taliep, R., Sorour, G., Nachman, S., Rabie, H., Dobbels, E., ... & Cotton, M. F. (2011). Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study. BMC research notes, 4(1), 448.en_ZA
dc.identifier.ris TY - Journal Article AU - Hainline, Clotilde AU - Taliep, Reghana AU - Sorour, Gill AU - Nachman, Sharon AU - Rabie, Helena AU - Dobbels, Els AU - van Rensburg, Anita AU - Cornell, Morna AU - Violari, Avy AU - Madhi, Shabir AU - Cotton, Mark AB - BACKGROUND: Although otorrhea occurs commonly in HIV-infected infants, there are few data. We compared the incidence of otorrhea in infants receiving early vs deferred ART in the Children with HIV Early Antiretroviral (CHER) trial. Infants aged 6 to 12 weeks of age with confirmed HIV infection and a CD4 percentage greater than or equal to 25% were randomized to early or deferred ART at two sites in South Africa. Medical records from one study site were reviewed for otorrhea.FINDINGS:Data were reviewed from the start of the trial in July 2005 until 20 June 2007, when the Data Safety Monitoring Board recommended that randomization to the deferred arm should stop and that all infants in this arm be reviewed for commencing antiretroviral therapy. Infants entered the study at a median of 7.4 weeks of age. Eleven of 38 (29%) on deferred therapy and 7 of 75 (9%) in the early-therapy group developed otorrhea (risk ratio 3.1, 95% confidence interval (CI) 1.31-7.36; p = 0.01). CONCLUSIONS: Early initiation of antiretroviral therapy is associated with significantly less otorrhea than when a deferred strategy is followed.TRIAL REGISTRATION:NCT00102960. ClinicalTrials.Gov DA - 2011 DB - OpenUCT DO - 10.1186/1756-0500-4-448 DP - University of Cape Town J1 - BMC Research Notes LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study TI - Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study UR - http://hdl.handle.net/11427/14910 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14910
dc.identifier.urihttp://dx.doi.org/10.1186/1756-0500-4-448
dc.identifier.vancouvercitationHainline C, Taliep R, Sorour G, Nachman S, Rabie H, Dobbels E, et al. Early Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study. BMC Research Notes. 2011; http://hdl.handle.net/11427/14910.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Cotton et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Research Notesen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcresnotes/contenten_ZA
dc.subject.otherOtorrheaen_ZA
dc.subject.otherearly ARTen_ZA
dc.subject.otherdeferred ARTen_ZA
dc.subject.otherHIV-infected infantsen_ZA
dc.subject.otherChildren with HIV Early Anti-retroviral (CHER) trialen_ZA
dc.titleEarly Antiretroviral Therapy reduces the incidence of otorrhea in a randomized study of early and deferred antiretroviral therapy: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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