Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking

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dc.contributor.advisorFranzidis, Jean-Paulen_ZA
dc.contributor.advisorBuffler, Andyen_ZA
dc.contributor.authorVan Heerden, Michael Rudien_ZA
dc.date.accessioned2017-05-16T07:59:13Z
dc.date.available2017-05-16T07:59:13Z
dc.date.issued2015en_ZA
dc.description.abstractPositron emission particle tracking (PEPT) is a technique which non-invasively tracks tracer particles labelled with a positron emitting radionuclide in a system of flow. The tracers are tracked through the detection in a PET scanner, of the two nearly collinear 511 keV gamma rays resulting from the annihilations of the positrons. For this technique to be effective, the tracer must be representative of the media in the system under study, and labelled with a sufficient activity of radionuclides. Organic ion exchange resins are suitable tracer materials for PEPT experiments, and are usually labelled with ⁶⁸Ga at the laboratories of PEPT Cape Town. The labelling performance relies on the chemical and physical properties of organic strongly acidic cation exchange resins and the nuclear chemistry of ⁶⁸Ga. The objective of this study is to obtain consistent tracer labelling throughout, or even beyond, the lifespan of the SnO₂ ⁶⁸Ge/⁶⁸Ga generator which degrades over time. The objective 1s achieved by integrating a purification technique into a "standard" radiolabelling method used at iThemba LABS. A small 0.5 ml Amberchrom CG-71 column is loaded with the ⁶⁸Ga generator eluent in 7 M HCl, then rinsed of most the contaminants before eluting the product with distilled water and used in the radiolabelling method. Using a 1-year-old 30 mCi SnO₂ ⁶⁸Ge/⁶⁸Ga generator eluent that has been purified by this method improved the radiolabelling performance by an average of at least 10% when compared to the performance of the un-purified product. Purifying the generator eluent will enable PEPT experiments of longer duration, and in highly shielded systems where tracers with high activity are required, such as granular and fluid flow in engineering applications.en_ZA
dc.identifier.apacitationVan Heerden, M. R. (2015). <i>Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking</i>. (Thesis). University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering. Retrieved from http://hdl.handle.net/11427/24310en_ZA
dc.identifier.chicagocitationVan Heerden, Michael Rudi. <i>"Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking."</i> Thesis., University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering, 2015. http://hdl.handle.net/11427/24310en_ZA
dc.identifier.citationVan Heerden, M. 2015. Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van Heerden, Michael Rudi AB - Positron emission particle tracking (PEPT) is a technique which non-invasively tracks tracer particles labelled with a positron emitting radionuclide in a system of flow. The tracers are tracked through the detection in a PET scanner, of the two nearly collinear 511 keV gamma rays resulting from the annihilations of the positrons. For this technique to be effective, the tracer must be representative of the media in the system under study, and labelled with a sufficient activity of radionuclides. Organic ion exchange resins are suitable tracer materials for PEPT experiments, and are usually labelled with ⁶⁸Ga at the laboratories of PEPT Cape Town. The labelling performance relies on the chemical and physical properties of organic strongly acidic cation exchange resins and the nuclear chemistry of ⁶⁸Ga. The objective of this study is to obtain consistent tracer labelling throughout, or even beyond, the lifespan of the SnO₂ ⁶⁸Ge/⁶⁸Ga generator which degrades over time. The objective 1s achieved by integrating a purification technique into a "standard" radiolabelling method used at iThemba LABS. A small 0.5 ml Amberchrom CG-71 column is loaded with the ⁶⁸Ga generator eluent in 7 M HCl, then rinsed of most the contaminants before eluting the product with distilled water and used in the radiolabelling method. Using a 1-year-old 30 mCi SnO₂ ⁶⁸Ge/⁶⁸Ga generator eluent that has been purified by this method improved the radiolabelling performance by an average of at least 10% when compared to the performance of the un-purified product. Purifying the generator eluent will enable PEPT experiments of longer duration, and in highly shielded systems where tracers with high activity are required, such as granular and fluid flow in engineering applications. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking TI - Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking UR - http://hdl.handle.net/11427/24310 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24310
dc.identifier.vancouvercitationVan Heerden MR. Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking. [Thesis]. University of Cape Town ,Faculty of Engineering & the Built Environment ,Department of Chemical Engineering, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/24310en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemical Engineeringen_ZA
dc.publisher.facultyFaculty of Engineering and the Built Environment
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemical Engineeringen_ZA
dc.titleImproving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle trackingen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Eng)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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