Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)

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dc.contributor.authorBanys-Paluchowski, Maggie
dc.contributor.authorKühn, Thorsten
dc.contributor.authorMasannat, Yazan
dc.contributor.authorRubio, Isabel
dc.contributor.authorde Boniface, Jana
dc.contributor.authorDitsch, Nina
dc.contributor.authorKaradeniz Cakmak, Güldeniz
dc.contributor.authorKarakatsanis, Andreas
dc.contributor.authorDave, Rajiv
dc.contributor.authorHahn, Markus
dc.contributor.authorPotter, Shelley
dc.contributor.authorKothari, Ashutosh
dc.contributor.authorGentilini, Oreste Davide
dc.contributor.authorGulluoglu, Bahadir M.
dc.contributor.authorLux, Michael Patrick
dc.contributor.authorSmidt, Marjolein
dc.contributor.authorWeber, Walter Paul
dc.contributor.authorAktas Sezen, Bilge
dc.contributor.authorKrawczyk, Natalia
dc.contributor.authorHartmann, Steffi
dc.contributor.authorDi Micco, Rosa
dc.contributor.authorNietz, Sarah
dc.contributor.authorMalherbe, Francois
dc.contributor.authorCabioglu, Neslihan
dc.contributor.authorCanturk, Nuh Zafer
dc.contributor.authorGasparri, Maria Luisa
dc.contributor.authorMurawa, Dawid
dc.contributor.authorHarvey, James
dc.date.accessioned2023-03-10T07:27:33Z
dc.date.available2023-03-10T07:27:33Z
dc.date.issued2023-02-12
dc.date.updated2023-02-24T14:09:37Z
dc.description.abstractBackground: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons’ and radiologists’ attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies.
dc.identifierdoi: 10.3390/cancers15041173
dc.identifier.apacitationBanys-Paluchowski, M., Kühn, T., Masannat, Y., Rubio, I., de Boniface, J., Ditsch, N., ... Harvey, J. (2023). Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411). <i>Cancers</i>,(15), http://hdl.handle.net/11427/37358en_ZA
dc.identifier.chicagocitationBanys-Paluchowski, Maggie, Thorsten Kühn, Yazan Masannat, Isabel Rubio, Jana de Boniface, Nina Ditsch, Güldeniz Karadeniz Cakmak, et al "Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)." <i>Cancers</i> 15. (2023) http://hdl.handle.net/11427/37358en_ZA
dc.identifier.citationBanys-Paluchowski, M., Kühn, T., Masannat, Y., Rubio, I., de Boniface, J., Ditsch, N., Karadeniz Cakmak, G. & Karakatsanis, A. et al. 2023. Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411). <i>Cancers.</i>(15) http://hdl.handle.net/11427/37358en_ZA
dc.identifier.risTY - Journal Article AU - Banys-Paluchowski, Maggie AU - Kühn, Thorsten AU - Masannat, Yazan AU - Rubio, Isabel AU - de Boniface, Jana AU - Ditsch, Nina AU - Karadeniz Cakmak, Güldeniz AU - Karakatsanis, Andreas AU - Dave, Rajiv AU - Hahn, Markus AU - Potter, Shelley AU - Kothari, Ashutosh AU - Gentilini, Oreste Davide AU - Gulluoglu, Bahadir M. AU - Lux, Michael Patrick AU - Smidt, Marjolein AU - Weber, Walter Paul AU - Aktas Sezen, Bilge AU - Krawczyk, Natalia AU - Hartmann, Steffi AU - Di Micco, Rosa AU - Nietz, Sarah AU - Malherbe, Francois AU - Cabioglu, Neslihan AU - Canturk, Nuh Zafer AU - Gasparri, Maria Luisa AU - Murawa, Dawid AU - Harvey, James AB - Background: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons&rsquo; and radiologists&rsquo; attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies. DA - 2023-02-12 DB - OpenUCT DP - University of Cape Town IS - 15 J1 - Cancers LK - https://open.uct.ac.za PY - 2023 T1 - Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411) TI - Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411) UR - http://hdl.handle.net/11427/37358 ER -en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/37358
dc.identifier.vancouvercitationBanys-Paluchowski M, Kühn T, Masannat Y, Rubio I, de Boniface J, Ditsch N, et al. Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411). Cancers. 2023;(15) http://hdl.handle.net/11427/37358.en_ZA
dc.publisherMultidisciplinary Digital Publishing Institute
dc.sourceCancers
dc.source.journalvolume15
dc.source.pagination1173
dc.source.urihttps://www.mdpi.com/journal/cancers
dc.titleLocalization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)
dc.typeJournal Article
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