Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America

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dc.contributor.authorZhou, Jialunen_ZA
dc.contributor.authorJaquet, Antoineen_ZA
dc.contributor.authorBissagnene, Emmanuelen_ZA
dc.contributor.authorMusick, Beverlyen_ZA
dc.contributor.authorWools-Kaloustian, Karaen_ZA
dc.contributor.authorMaxwell, Nicolaen_ZA
dc.contributor.authorBoulle, Andrewen_ZA
dc.contributor.authorWehbe, Firasen_ZA
dc.contributor.authorMasys, Danielen_ZA
dc.contributor.authorIriondo-Perez, Jenifferen_ZA
dc.contributor.authorHemingway-Foday, Jayen_ZA
dc.contributor.authorLaw, Matthewen_ZA
dc.contributor.authorthe western Africa, eastern Africen_ZA
dc.date.accessioned2015-11-23T12:10:21Z
dc.date.available2015-11-23T12:10:21Z
dc.date.issued2012en_ZA
dc.description.abstractBACKGROUND:The objective was to examine the short-term risk and predictors of anaemia following initiation of combination antiretroviral therapy (cART) in HIV-infected patients from the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian-Pacific, and Caribbean and Central and South America regions of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) collaboration. METHODS: Anaemia was defined as haemoglobin of < 10 g/dL. Patients were included if they started cART with three or more drugs, had prior haemoglobin of > = 10 g/dL, and had one or more follow-up haemoglobin tests. Factors associated with anaemia up to 12 months were examined using Cox proportional hazards models and stratified by IeDEA region. RESULTS: Between 1998 and 2008, 19,947 patients initiated cART with baseline and follow-up haemoglobin tests (7358, 7289, 2853, 471, 1550 and 426 in the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian-Pacific, and Caribbean and Central and South America regions, respectively). At initiation, anaemia was found in 45% of Western Africa patients, 29% of Eastern Africa patients, 21% of Southern Africa patients, 36% of Central Africa patients, 15% of patients in Asian-Pacific and 14% of patients in Caribbean and Central and South America. Among patients with haemoglobin of > = 10 g/dL at baseline (13,445), the risks of anaemia were 18.2, 6.6, 9.7, 22.9, 11.8 and 19.5 per 100 person-years in the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian, and Caribbean and Central and South America regions, respectively. Factors associated with anaemia were female sex, low baseline haemoglobin level, low baseline CD4 count, more advanced disease stage, and initial cART containing zidovudine. CONCLUSIONS: In data from 34 cohorts of HIV-infected patients from sub-Saharan Africa, Central and South America, and Asia, the risk of anaemia within 12 months of initiating cART was moderate. Routine haemoglobin monitoring was recommended in patients at risk of developing anaemia following cART initiation.en_ZA
dc.identifier.apacitationZhou, J., Jaquet, A., Bissagnene, E., Musick, B., Wools-Kaloustian, K., Maxwell, N., ... the western Africa, e. A. (2012). Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America. <i>Journal of the International AIDS Society</i>, http://hdl.handle.net/11427/15264en_ZA
dc.identifier.chicagocitationZhou, Jialun, Antoine Jaquet, Emmanuel Bissagnene, Beverly Musick, Kara Wools-Kaloustian, Nicola Maxwell, Andrew Boulle, et al "Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America." <i>Journal of the International AIDS Society</i> (2012) http://hdl.handle.net/11427/15264en_ZA
dc.identifier.citationZhou, J., Jaquet, A., Bissagnene, E., Musick, B., Wools-Kaloustian, K., Maxwell, N., ... & Law, M. (2012). Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America. Journal of the International AIDS Society, 15(1), 5.en_ZA
dc.identifier.ris TY - Journal Article AU - Zhou, Jialun AU - Jaquet, Antoine AU - Bissagnene, Emmanuel AU - Musick, Beverly AU - Wools-Kaloustian, Kara AU - Maxwell, Nicola AU - Boulle, Andrew AU - Wehbe, Firas AU - Masys, Daniel AU - Iriondo-Perez, Jeniffer AU - Hemingway-Foday, Jay AU - Law, Matthew AU - the western Africa, eastern Afric AB - BACKGROUND:The objective was to examine the short-term risk and predictors of anaemia following initiation of combination antiretroviral therapy (cART) in HIV-infected patients from the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian-Pacific, and Caribbean and Central and South America regions of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) collaboration. METHODS: Anaemia was defined as haemoglobin of < 10 g/dL. Patients were included if they started cART with three or more drugs, had prior haemoglobin of > = 10 g/dL, and had one or more follow-up haemoglobin tests. Factors associated with anaemia up to 12 months were examined using Cox proportional hazards models and stratified by IeDEA region. RESULTS: Between 1998 and 2008, 19,947 patients initiated cART with baseline and follow-up haemoglobin tests (7358, 7289, 2853, 471, 1550 and 426 in the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian-Pacific, and Caribbean and Central and South America regions, respectively). At initiation, anaemia was found in 45% of Western Africa patients, 29% of Eastern Africa patients, 21% of Southern Africa patients, 36% of Central Africa patients, 15% of patients in Asian-Pacific and 14% of patients in Caribbean and Central and South America. Among patients with haemoglobin of > = 10 g/dL at baseline (13,445), the risks of anaemia were 18.2, 6.6, 9.7, 22.9, 11.8 and 19.5 per 100 person-years in the Western Africa, Eastern Africa, Southern Africa, Central Africa, Asian, and Caribbean and Central and South America regions, respectively. Factors associated with anaemia were female sex, low baseline haemoglobin level, low baseline CD4 count, more advanced disease stage, and initial cART containing zidovudine. CONCLUSIONS: In data from 34 cohorts of HIV-infected patients from sub-Saharan Africa, Central and South America, and Asia, the risk of anaemia within 12 months of initiating cART was moderate. Routine haemoglobin monitoring was recommended in patients at risk of developing anaemia following cART initiation. DA - 2012 DB - OpenUCT DO - 10.1186/1758-2652-15-5 DP - University of Cape Town J1 - Journal of the International AIDS Society LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America TI - Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America UR - http://hdl.handle.net/11427/15264 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15264
dc.identifier.urihttp://dx.doi.org/10.1186/1758-2652-15-5
dc.identifier.vancouvercitationZhou J, Jaquet A, Bissagnene E, Musick B, Wools-Kaloustian K, Maxwell N, et al. Short-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South America. Journal of the International AIDS Society. 2012; http://hdl.handle.net/11427/15264.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2012 Zhou et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of the International AIDS Societyen_ZA
dc.source.urihttp://archive.biomedcentral.com/1758-2652/en_ZA
dc.subject.otheranaemia short-term risken_ZA
dc.subject.otheranaemia predictorsen_ZA
dc.subject.otherantiretroviral therapy (cART)en_ZA
dc.subject.otherHIV-infected patientsen_ZA
dc.titleShort-term risk of anaemia following initiation of combination antiretroviral treatment in HIV-infected patients in countries in sub-Saharan Africa, Asia-Pacific, and central and South Americaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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