Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review

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dc.contributor.advisorEhrlich, Rodneyen_ZA
dc.contributor.advisorEngel, Mark Een_ZA
dc.contributor.authorSchmidt, Bey-Marrieen_ZA
dc.date.accessioned2016-06-02T08:48:56Z
dc.date.available2016-06-02T08:48:56Z
dc.date.issued2015en_ZA
dc.description.abstractBackground: Tuberculosis is a major cause of morbidity and mortality as an estimated 8.6 million people developed TB and 1.3 million died from the disease in 2012. The number of deaths is high given that TB can be prevented. Health care workers are an at - risk group, since they are frequently in contact with infectious patients and/or work with infectious products. The World Health Organisation has declared the importance of finding innovative tools and strategies to prevent TB and implementing them successfully, especially for those with a high risk of TB transmission. Methods: This systematic review aims to undertake a quantitative review of tuberculosis interventions for health care workers in health care settings, so as to assess whether these interventions are effective in reducing the transmission of tuberculosis infection and disease. We will preferably include experimental studies, such as, randomised - controlled trials, but observational studies, such as controlled before and after studies and cohort studies will also be included in the absence of randomised - controlled studies. We will search databases, such as Medline, Scopus, Trip, LILACS and various trial registries. A hand search of reference lists of identified articles, abstracts, conference proceedings and campaign materials will be performed. Grey literature sites will also be used for the search. Data will be extracted using a single form. The quality of each study will be assessed in terms of selection bias, performance bias, attrition bias and detection bias. Thereafter a meta - analysis will be produced and subgroups will be analysed according to the three intervention types. Clinical and statistical significance will be determined for the included studies, and descriptive narratives of heterogeneous studies will be written. Discussion: Our results will be useful to policy - makers and public health officials for the prioritisation of those interventions identified as effective and critical .en_ZA
dc.identifier.apacitationSchmidt, B. (2015). <i>Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/19906en_ZA
dc.identifier.chicagocitationSchmidt, Bey-Marrie. <i>"Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2015. http://hdl.handle.net/11427/19906en_ZA
dc.identifier.citationSchmidt, B. 2015. Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Schmidt, Bey-Marrie AB - Background: Tuberculosis is a major cause of morbidity and mortality as an estimated 8.6 million people developed TB and 1.3 million died from the disease in 2012. The number of deaths is high given that TB can be prevented. Health care workers are an at - risk group, since they are frequently in contact with infectious patients and/or work with infectious products. The World Health Organisation has declared the importance of finding innovative tools and strategies to prevent TB and implementing them successfully, especially for those with a high risk of TB transmission. Methods: This systematic review aims to undertake a quantitative review of tuberculosis interventions for health care workers in health care settings, so as to assess whether these interventions are effective in reducing the transmission of tuberculosis infection and disease. We will preferably include experimental studies, such as, randomised - controlled trials, but observational studies, such as controlled before and after studies and cohort studies will also be included in the absence of randomised - controlled studies. We will search databases, such as Medline, Scopus, Trip, LILACS and various trial registries. A hand search of reference lists of identified articles, abstracts, conference proceedings and campaign materials will be performed. Grey literature sites will also be used for the search. Data will be extracted using a single form. The quality of each study will be assessed in terms of selection bias, performance bias, attrition bias and detection bias. Thereafter a meta - analysis will be produced and subgroups will be analysed according to the three intervention types. Clinical and statistical significance will be determined for the included studies, and descriptive narratives of heterogeneous studies will be written. Discussion: Our results will be useful to policy - makers and public health officials for the prioritisation of those interventions identified as effective and critical . DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review TI - Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review UR - http://hdl.handle.net/11427/19906 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/19906
dc.identifier.vancouvercitationSchmidt B. Tuberculosis interventions to prevent transmission of infection in health care workers: a systematic review. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/19906en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.titleTuberculosis interventions to prevent transmission of infection in health care workers: a systematic reviewen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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