Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa

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dc.contributor.authorFirnhaber, Cynthiaen_ZA
dc.contributor.authorGoeieman, Bridgetteen_ZA
dc.contributor.authorFaesen, Marken_ZA
dc.contributor.authorLevin, Simonen_ZA
dc.contributor.authorWilliams, Sophieen_ZA
dc.contributor.authorRameotshela, Sibongileen_ZA
dc.contributor.authorSwarts, Avrilen_ZA
dc.contributor.authorMichelow, Pamen_ZA
dc.contributor.authorOmar, Tanvieren_ZA
dc.contributor.authorWilliamson, Anna-Liseen_ZA
dc.contributor.authorAllan, Bruceen_ZA
dc.contributor.authorSchnippel, Kateen_ZA
dc.contributor.authorSmith, Jennifer Sen_ZA
dc.date.accessioned2016-02-10T14:45:05Z
dc.date.available2016-02-10T14:45:05Z
dc.date.issued2016en_ZA
dc.description.abstractBACKGROUND: Cervical cancer is the most common cancer in Sub-Saharan Africa. There are little of HIV-infected women one-year after screening using visual inspection with acetic acid (VIA), HPV or cytology in sub-Saharan Africa. METHODS: HIV-infected women in Johannesburg South Africa were screened one year later by Pap smear, VIA and human papillomavirus (HPV) testing. Women qualified for the 12 month follow-up visit if they had a negative or cervical intra-epithelial neoplasia (CIN) 1 results at the baseline visit. Modified Poisson regression was used to analyse associations between patient baseline characteristics and progression. RESULTS: A total of 688 of 1,202 enrolled at baseline study who were CIN-2+ negative and qualified for a 12 month follow-up visit. Progression to CIN-2+ was higher in women with positive VIA results (12.6%; 24/191) than those VIA-negative (4.4%; 19/432). HPV-positive women at baseline were more likely to progress to CIN-2+ (12.3%; 36/293) than those HPV-negative (2.1%; 7/329). Cytology-positive women at baseline were more likely to progress to CIN-2+ (9.6%; 37/384) than cytology-negative women (2.5%; 6/237). Approximately 10% (10.4%; 39/376) of women with CIN 1 at baseline progressed to CIN 2+. Women who were VIA or HPV positive at baseline were more likely to progress aIRR 1.85, CI 95% (1.46 to 2.36), aIRR 1.41 CI 95% (1.14 to 1.75) respectively. CONCLUSION: Progression to CIN-2+ in HIV-infected women is significant when measured by baseline positive VIA, HPV or Pap and yearly screening by any method should be considered in this population if possible.en_ZA
dc.identifier.apacitationFirnhaber, C., Goeieman, B., Faesen, M., Levin, S., Williams, S., Rameotshela, S., ... Smith, J. S. (2016). Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16942en_ZA
dc.identifier.chicagocitationFirnhaber, Cynthia, Bridgette Goeieman, Mark Faesen, Simon Levin, Sophie Williams, Sibongile Rameotshela, Avril Swarts, et al "Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/16942en_ZA
dc.identifier.citationFirnhaber, C., Goeieman, B., Faesen, M., Levin, S., Williams, S., Rameotshela, S., ... & Allan, B. (2015). Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa. PloS one, 11(1), e0144905. doi:10.1371/journal.pone.0144905en_ZA
dc.identifier.ris TY - Journal Article AU - Firnhaber, Cynthia AU - Goeieman, Bridgette AU - Faesen, Mark AU - Levin, Simon AU - Williams, Sophie AU - Rameotshela, Sibongile AU - Swarts, Avril AU - Michelow, Pam AU - Omar, Tanvier AU - Williamson, Anna-Lise AU - Allan, Bruce AU - Schnippel, Kate AU - Smith, Jennifer S AB - BACKGROUND: Cervical cancer is the most common cancer in Sub-Saharan Africa. There are little of HIV-infected women one-year after screening using visual inspection with acetic acid (VIA), HPV or cytology in sub-Saharan Africa. METHODS: HIV-infected women in Johannesburg South Africa were screened one year later by Pap smear, VIA and human papillomavirus (HPV) testing. Women qualified for the 12 month follow-up visit if they had a negative or cervical intra-epithelial neoplasia (CIN) 1 results at the baseline visit. Modified Poisson regression was used to analyse associations between patient baseline characteristics and progression. RESULTS: A total of 688 of 1,202 enrolled at baseline study who were CIN-2+ negative and qualified for a 12 month follow-up visit. Progression to CIN-2+ was higher in women with positive VIA results (12.6%; 24/191) than those VIA-negative (4.4%; 19/432). HPV-positive women at baseline were more likely to progress to CIN-2+ (12.3%; 36/293) than those HPV-negative (2.1%; 7/329). Cytology-positive women at baseline were more likely to progress to CIN-2+ (9.6%; 37/384) than cytology-negative women (2.5%; 6/237). Approximately 10% (10.4%; 39/376) of women with CIN 1 at baseline progressed to CIN 2+. Women who were VIA or HPV positive at baseline were more likely to progress aIRR 1.85, CI 95% (1.46 to 2.36), aIRR 1.41 CI 95% (1.14 to 1.75) respectively. CONCLUSION: Progression to CIN-2+ in HIV-infected women is significant when measured by baseline positive VIA, HPV or Pap and yearly screening by any method should be considered in this population if possible. DA - 2016 DB - OpenUCT DO - 10.1371/journal.pone.0144905 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa TI - Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa UR - http://hdl.handle.net/11427/16942 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0144905en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16942
dc.identifier.vancouvercitationFirnhaber C, Goeieman B, Faesen M, Levin S, Williams S, Rameotshela S, et al. Prospective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africa. PLoS One. 2016; http://hdl.handle.net/11427/16942.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Firnhaber et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHistologyen_ZA
dc.subject.otherCytologyen_ZA
dc.subject.otherCervical canceren_ZA
dc.subject.otherBiopsyen_ZA
dc.subject.otherCancer screeningen_ZA
dc.subject.otherHuman papillomavirus infectionen_ZA
dc.subject.otherScreening guidelinesen_ZA
dc.subject.otherHuman papillomavirusen_ZA
dc.titleProspective One Year follow up of HIV infected women screened for cervical cancer using visual inspection with acetic acid, cytology and human papillomavirus testing in Johannesburg, South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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