Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents

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dc.contributor.advisorHunter, Rogeren_ZA
dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.authorQwebani, Tozamaen_ZA
dc.date.accessioned2014-11-05T17:41:59Z
dc.date.available2014-11-05T17:41:59Z
dc.date.issued2009en_ZA
dc.descriptionIncludes bibliographical references (leaves 107-111).en_ZA
dc.description.abstractThe first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies.en_ZA
dc.identifier.apacitationQwebani, T. (2009). <i>Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/9281en_ZA
dc.identifier.chicagocitationQwebani, Tozama. <i>"Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009. http://hdl.handle.net/11427/9281en_ZA
dc.identifier.citationQwebani, T. 2009. Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Qwebani, Tozama AB - The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents TI - Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents UR - http://hdl.handle.net/11427/9281 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9281
dc.identifier.vancouvercitationQwebani T. Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9281en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleStudies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agentsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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