Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa

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dc.contributor.advisorWebb, Kate
dc.contributor.advisorScott, Christiaan
dc.contributor.authorPhoya, Frank
dc.date.accessioned2026-01-22T07:17:14Z
dc.date.available2026-01-22T07:17:14Z
dc.date.issued2025
dc.date.updated2026-01-22T07:11:57Z
dc.description.abstractBackground: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care.
dc.identifier.apacitationPhoya, F. (2025). <i>Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/42646en_ZA
dc.identifier.chicagocitationPhoya, Frank. <i>"Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025. http://hdl.handle.net/11427/42646en_ZA
dc.identifier.citationPhoya, F. 2025. Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa. . University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/42646en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Phoya, Frank AB - Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Multisystem inflammatory syndrome KW - Children KW - Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa TI - Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa UR - http://hdl.handle.net/11427/42646 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/42646
dc.identifier.vancouvercitationPhoya F. Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa. []. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/42646en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectMultisystem inflammatory syndrome
dc.subjectChildren
dc.subjectCape Town
dc.titleMedium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMasters
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