Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype

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dc.contributor.authorDalvie, S
dc.contributor.authorHorn, Neil
dc.contributor.authorNossek, Christel
dc.contributor.authorvan der Merwe, L
dc.contributor.authorStein, Dan
dc.contributor.authorRamesar, Raj
dc.date.accessioned2017-05-29T11:35:12Z
dc.date.available2017-05-29T11:35:12Z
dc.date.issued2010
dc.date.updated2016-01-08T10:54:09Z
dc.description.abstractObjective: Dysfunction in glutamate signalling is thought to play a role in the pathophysiology of bipolar disorder (BD). There is evidence of associations between single nucleotide polymorphisms (SNPs) in GRM3, GRIN2B, and DAOA genes and the diagnosis of BD. In this pilot study, we investigated the frequency of SNP variants in these 3 genes within South African population groups, and assessed interactions between genes and phenotypes of BD disease severity. Method: Multiplex SNaPshotTM PCR was used to genotype 191 case and 188 control samples. Cases comprised of 191 individuals in a South African cohort of mixed ancestry and Caucasians, with BD Type 1. Phenotypes of BD disease severity were: age of onset, number of illness episodes, number of hospitalisations for depression or mania and history of psychotic symptoms. Results: There were no significant difference in SNP allele frequencies between cases and controls. In the case-only analysis, the GRM3 rs6465084 heterozygote was associated with a 4-fold increased risk of lifetime history of psychotic symptoms, and the specific variants within the gene pair, DAOA and GRIN2B, had a significant interaction with the number of hospitalisations for mania, with lowest admission rates associated with both pairs of ancestral alleles.Conclusion: In BD, variations in glutamatergic genes may influence phenotypes related to the severity of illness. Speculatively, newly derived genes associated with various evolutionary advantages, may also increase the risk for more severe BD. These preliminary findings deserve validation in a larger cohort.
dc.identifier.apacitationDalvie, S., Horn, N., Nossek, C., van der Merwe, L., Stein, D., & Ramesar, R. (2010). Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype. <i>African Journal of Psychiatry</i>, http://hdl.handle.net/11427/24430en_ZA
dc.identifier.chicagocitationDalvie, S, Neil Horn, Christel Nossek, L van der Merwe, Dan Stein, and Raj Ramesar "Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype." <i>African Journal of Psychiatry</i> (2010) http://hdl.handle.net/11427/24430en_ZA
dc.identifier.citationDalvie, S., Horn, N., Nossek, C., Van der Merwe, L., Stein, D. J., & Ramesar, R. (2010). Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype. African journal of psychiatry, 13(4).
dc.identifier.ris TY - Journal Article AU - Dalvie, S AU - Horn, Neil AU - Nossek, Christel AU - van der Merwe, L AU - Stein, Dan AU - Ramesar, Raj AB - Objective: Dysfunction in glutamate signalling is thought to play a role in the pathophysiology of bipolar disorder (BD). There is evidence of associations between single nucleotide polymorphisms (SNPs) in GRM3, GRIN2B, and DAOA genes and the diagnosis of BD. In this pilot study, we investigated the frequency of SNP variants in these 3 genes within South African population groups, and assessed interactions between genes and phenotypes of BD disease severity. Method: Multiplex SNaPshotTM PCR was used to genotype 191 case and 188 control samples. Cases comprised of 191 individuals in a South African cohort of mixed ancestry and Caucasians, with BD Type 1. Phenotypes of BD disease severity were: age of onset, number of illness episodes, number of hospitalisations for depression or mania and history of psychotic symptoms. Results: There were no significant difference in SNP allele frequencies between cases and controls. In the case-only analysis, the GRM3 rs6465084 heterozygote was associated with a 4-fold increased risk of lifetime history of psychotic symptoms, and the specific variants within the gene pair, DAOA and GRIN2B, had a significant interaction with the number of hospitalisations for mania, with lowest admission rates associated with both pairs of ancestral alleles.Conclusion: In BD, variations in glutamatergic genes may influence phenotypes related to the severity of illness. Speculatively, newly derived genes associated with various evolutionary advantages, may also increase the risk for more severe BD. These preliminary findings deserve validation in a larger cohort. DA - 2010 DB - OpenUCT DP - University of Cape Town J1 - African Journal of Psychiatry LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype TI - Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype UR - http://hdl.handle.net/11427/24430 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24430
dc.identifier.vancouvercitationDalvie S, Horn N, Nossek C, van der Merwe L, Stein D, Ramesar R. Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype. African Journal of Psychiatry. 2010; http://hdl.handle.net/11427/24430.en_ZA
dc.language.isoeng
dc.publisher.departmentMRC/UCT Human Genetics Research Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceAfrican Journal of Psychiatry
dc.source.urihttps://www.omicsonline.com/open-access/african-journal-of-psychiatry.php
dc.subject.otherManic-Depressive Psychosis
dc.subject.otherGlutamate
dc.subject.otherGRIN2B receptor
dc.subject.othermGluR3
dc.subject.otherG72 protein
dc.subject.otherHuman
dc.titlePsychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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