Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract

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dc.contributor.authorAdefuye, Anthonio O
dc.contributor.authorAdeola, Henry A
dc.contributor.authorSales, Kurt J
dc.contributor.authorKatz, Arieh A
dc.date.accessioned2021-10-08T07:08:14Z
dc.date.available2021-10-08T07:08:14Z
dc.date.issued2016
dc.description.abstractInflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. In addition, based on findings from TaqMan® 96-Well Plate Arrays, on neoplastic cervical cells treated with SF, we discuss new findings on the role of SF as a potent driver of inflammatory and tumorigenic pathways in the cervix.
dc.identifier.apacitationAdefuye, A. O., Adeola, H. A., Sales, K. J., & Katz, A. A. (2016). Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract. <i>Journal of Immunology Research</i>, 2016(4), 174 - 177. http://hdl.handle.net/11427/34529en_ZA
dc.identifier.chicagocitationAdefuye, Anthonio O, Henry A Adeola, Kurt J Sales, and Arieh A Katz "Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract." <i>Journal of Immunology Research</i> 2016, 4. (2016): 174 - 177. http://hdl.handle.net/11427/34529en_ZA
dc.identifier.citationAdefuye, A.O., Adeola, H.A., Sales, K.J. & Katz, A.A. 2016. Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract. <i>Journal of Immunology Research.</i> 2016(4):174 - 177. http://hdl.handle.net/11427/34529en_ZA
dc.identifier.issn2314-7156
dc.identifier.issn2314-8861
dc.identifier.ris TY - Journal Article AU - Adefuye, Anthonio O AU - Adeola, Henry A AU - Sales, Kurt J AU - Katz, Arieh A AB - Inflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. In addition, based on findings from TaqMan® 96-Well Plate Arrays, on neoplastic cervical cells treated with SF, we discuss new findings on the role of SF as a potent driver of inflammatory and tumorigenic pathways in the cervix. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - Journal of Immunology Research LK - https://open.uct.ac.za PY - 2016 SM - 2314-7156 SM - 2314-8861 T1 - Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract TI - Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract UR - http://hdl.handle.net/11427/34529 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34529
dc.identifier.vancouvercitationAdefuye AO, Adeola HA, Sales KJ, Katz AA. Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract. Journal of Immunology Research. 2016;2016(4):174 - 177. http://hdl.handle.net/11427/34529.en_ZA
dc.publisher.departmentDepartment of Pathology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceJournal of Immunology Research
dc.source.journalissue4
dc.source.journalvolume2016
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1155/2016/9707252
dc.subject.otherAllergens
dc.subject.otherCell Transformation, Neoplastic
dc.subject.otherFemale
dc.subject.otherGenital Diseases, Female
dc.subject.otherGenital Neoplasms, Female
dc.subject.otherGenitalia, Female
dc.subject.otherHumans
dc.subject.otherImmunity
dc.subject.otherInflammation
dc.subject.otherInflammation Mediators
dc.subject.otherMale
dc.subject.otherPregnancy
dc.subject.otherRisk Factors
dc.titleSeminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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