Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy

Simple item page
dc.contributor.advisorMaartens, Garyen_ZA
dc.contributor.authorCourt, Richard Grayen_ZA
dc.date.accessioned2015-08-27T12:35:09Z
dc.date.available2015-08-27T12:35:09Z
dc.date.issued2015en_ZA
dc.description.abstractThe management of patients failing second line antiretroviral therapy (ART) is a critical area of study considering the increasing numbers of patients on second line regimens, and the expense and poor availability of third line ART. Most patients who experience virologic failure (VF) on second line ART in low-middle income countries fail due to poor adherence rather than antiretroviral resistance. Pharmacy refill is an easily implementable adherence measure which has shown to correlate with viral load monitoring and survival, and has potential over the short term to be used as a simple adherence tool to detect probable VF on second line ART. The benefit would be conservation of resources by rationally limiting need for viral load (VL) testing and, in those countries with access to third line ART, the need for resistance testing. We conducted an observational cohort study of patients who initiated second line ART at the McCord hospital ART clinic, “Sinikithemba†in Kwazulu-Natal, South Africa. Using clinical and pharmacy refill data extracted from the clinic’s electronic database, we determined risk factors for VF. Three different methods of calculating short term pharmacy refill adherence were evaluated and compared with long term adherence after second line initiation. Different interval durations of short term pharmacy refill were also assessed to determine the optimum time period of pharmacy refill that correlates best with a virologic response on second line ART.en_ZA
dc.identifier.apacitationCourt, R. G. (2015). <i>Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/13801en_ZA
dc.identifier.chicagocitationCourt, Richard Gray. <i>"Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2015. http://hdl.handle.net/11427/13801en_ZA
dc.identifier.citationCourt, R. 2015. Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Court, Richard Gray AB - The management of patients failing second line antiretroviral therapy (ART) is a critical area of study considering the increasing numbers of patients on second line regimens, and the expense and poor availability of third line ART. Most patients who experience virologic failure (VF) on second line ART in low-middle income countries fail due to poor adherence rather than antiretroviral resistance. Pharmacy refill is an easily implementable adherence measure which has shown to correlate with viral load monitoring and survival, and has potential over the short term to be used as a simple adherence tool to detect probable VF on second line ART. The benefit would be conservation of resources by rationally limiting need for viral load (VL) testing and, in those countries with access to third line ART, the need for resistance testing. We conducted an observational cohort study of patients who initiated second line ART at the McCord hospital ART clinic, “Sinikithemba†in Kwazulu-Natal, South Africa. Using clinical and pharmacy refill data extracted from the clinic’s electronic database, we determined risk factors for VF. Three different methods of calculating short term pharmacy refill adherence were evaluated and compared with long term adherence after second line initiation. Different interval durations of short term pharmacy refill were also assessed to determine the optimum time period of pharmacy refill that correlates best with a virologic response on second line ART. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy TI - Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy UR - http://hdl.handle.net/11427/13801 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13801
dc.identifier.vancouvercitationCourt RG. Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13801en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleShort term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2015_court_richard_gray.pdf
Size:
871.23 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters