Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults

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dc.contributor.authorHarbron, Janetta
dc.contributor.authorvan der Merwe, Lize
dc.contributor.authorZaahl, Monique
dc.contributor.authorKotze, Maritha
dc.contributor.authorSenekal, Marjanne
dc.date.accessioned2021-10-08T07:08:29Z
dc.date.available2021-10-08T07:08:29Z
dc.date.issued2014
dc.description.abstractThe fat mass and obesity-associated (FTO) gene is currently recognized as the most robust predictor of polygenic obesity. We investigated associations between the FTO rs1421085 and rs17817449 polymorphisms and the FTO rs1421085–rs17817449 haplotype and dietary intake, eating behavior, physical activity, and psychological health, as well as the effect of these associations on BMI. N = 133 treatment seeking overweight/obese Caucasian adults participated in this study. Genotyping was performed from whole blood samples. Weight and height was measured and a non-quantified food frequency questionnaire was completed to assess food group intake. Validated questionnaires were completed to assess physical activity (Baecke questionnaire), psychological health (General Health questionnaire, Rosenburg self-esteem scale and Beck Depression Inventory), and eating behavior (Three Factor Eating questionnaire). The risk alleles of the FTO polymorphisms were associated with poorer eating behaviors (higher hunger, internal locus for hunger, and emotional disinhibition scores), a higher intake of high fat foods and refined starches and more depressive symptoms. The modeled results indicate that interactions between the FTO polymorphisms or haplotypes and eating behavior, psychological health, and physical activity levels may be associated with BMI. The clinical significance of these results for implementation as part of weight management interventions needs further investigation.
dc.identifier.apacitationHarbron, J., van der Merwe, L., Zaahl, M., Kotze, M., & Senekal, M. (2014). Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults. <i>Nutrients</i>, 6(8), 3130 - 3152. http://hdl.handle.net/11427/34590en_ZA
dc.identifier.chicagocitationHarbron, Janetta, Lize van der Merwe, Monique Zaahl, Maritha Kotze, and Marjanne Senekal "Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults." <i>Nutrients</i> 6, 8. (2014): 3130 - 3152. http://hdl.handle.net/11427/34590en_ZA
dc.identifier.citationHarbron, J., van der Merwe, L., Zaahl, M., Kotze, M. & Senekal, M. 2014. Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults. <i>Nutrients.</i> 6(8):3130 - 3152. http://hdl.handle.net/11427/34590en_ZA
dc.identifier.issn2072-6643
dc.identifier.ris TY - Journal Article AU - Harbron, Janetta AU - van der Merwe, Lize AU - Zaahl, Monique AU - Kotze, Maritha AU - Senekal, Marjanne AB - The fat mass and obesity-associated (FTO) gene is currently recognized as the most robust predictor of polygenic obesity. We investigated associations between the FTO rs1421085 and rs17817449 polymorphisms and the FTO rs1421085–rs17817449 haplotype and dietary intake, eating behavior, physical activity, and psychological health, as well as the effect of these associations on BMI. N = 133 treatment seeking overweight/obese Caucasian adults participated in this study. Genotyping was performed from whole blood samples. Weight and height was measured and a non-quantified food frequency questionnaire was completed to assess food group intake. Validated questionnaires were completed to assess physical activity (Baecke questionnaire), psychological health (General Health questionnaire, Rosenburg self-esteem scale and Beck Depression Inventory), and eating behavior (Three Factor Eating questionnaire). The risk alleles of the FTO polymorphisms were associated with poorer eating behaviors (higher hunger, internal locus for hunger, and emotional disinhibition scores), a higher intake of high fat foods and refined starches and more depressive symptoms. The modeled results indicate that interactions between the FTO polymorphisms or haplotypes and eating behavior, psychological health, and physical activity levels may be associated with BMI. The clinical significance of these results for implementation as part of weight management interventions needs further investigation. DA - 2014 DB - OpenUCT DP - University of Cape Town IS - 8 J1 - Nutrients LK - https://open.uct.ac.za PY - 2014 SM - 2072-6643 T1 - Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults TI - Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults UR - http://hdl.handle.net/11427/34590 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34590
dc.identifier.vancouvercitationHarbron J, van der Merwe L, Zaahl M, Kotze M, Senekal M. Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults. Nutrients. 2014;6(8):3130 - 3152. http://hdl.handle.net/11427/34590.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Human Nutrition
dc.publisher.facultyFaculty of Health Sciences
dc.sourceNutrients
dc.source.journalissue8
dc.source.journalvolume6
dc.source.pagination3130 - 3152
dc.source.urihttps://dx.doi.org/10.3390/nu6083130
dc.subject.otherAdult
dc.subject.otherAlpha-Ketoglutarate-Dependent Dioxygenase FTO
dc.subject.otherBody Mass Index
dc.subject.otherBody Weight
dc.subject.otherCross-Sectional Studies
dc.subject.otherEnergy Intake
dc.subject.otherEuropean Continental Ancestry Group
dc.subject.otherFeeding Behavior
dc.subject.otherFemale
dc.subject.otherFollow-Up Studies
dc.subject.otherGene Frequency
dc.subject.otherGenotype
dc.subject.otherHumans
dc.subject.otherMale
dc.subject.otherMental Health
dc.subject.otherMotor Activity
dc.subject.otherObesity
dc.subject.otherOverweight
dc.subject.otherPolymorphism, Genetic
dc.titleFat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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