The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR

Simple item page
dc.contributor.advisorMeyers, Paulen_ZA
dc.contributor.authorStegmann, Darren Edwarden_ZA
dc.date.accessioned2015-07-14T08:42:37Z
dc.date.available2015-07-14T08:42:37Z
dc.date.issued2011en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractAs part of an antibiotic-screening programme, an actinomycete, Streptomyces polyantibioticus SPRT, was isolated from soil collected from the banks of the Umgeni River, KwaZulu-Natal Province, South Africa. It exhibited antibiosis against M. tuberculosis H37RvT, prompting interest in its antibiotic production. An antibiotic produced by S. polyantibioticus SPRT was isolated and its structure determined by nuclear magnetic resonance (NMR) and X-ray crystallography to be 2,5- diphenyloxazole (DPO). Of great interest is the independent confirmation of the antibiotic activity of DPO and extension of the data to show activity against non-replicating persistent cells of M. tuberculosis. It seems likely that 2,5-DPO is synthesized non-ribosomally by S. polyantibioticus SPRT. It is proposed that DPO is synthesised from the starting units of benzoic acid and -hydroxyphenylalanine or phenylalanine, undergoing peptide bond formation followed by cyclization and decarboxylation to form DPO.en_ZA
dc.identifier.apacitationStegmann, D. E. (2011). <i>The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/13421en_ZA
dc.identifier.chicagocitationStegmann, Darren Edward. <i>"The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011. http://hdl.handle.net/11427/13421en_ZA
dc.identifier.citationStegmann, D. 2011. The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Stegmann, Darren Edward AB - As part of an antibiotic-screening programme, an actinomycete, Streptomyces polyantibioticus SPRT, was isolated from soil collected from the banks of the Umgeni River, KwaZulu-Natal Province, South Africa. It exhibited antibiosis against M. tuberculosis H37RvT, prompting interest in its antibiotic production. An antibiotic produced by S. polyantibioticus SPRT was isolated and its structure determined by nuclear magnetic resonance (NMR) and X-ray crystallography to be 2,5- diphenyloxazole (DPO). Of great interest is the independent confirmation of the antibiotic activity of DPO and extension of the data to show activity against non-replicating persistent cells of M. tuberculosis. It seems likely that 2,5-DPO is synthesized non-ribosomally by S. polyantibioticus SPRT. It is proposed that DPO is synthesised from the starting units of benzoic acid and -hydroxyphenylalanine or phenylalanine, undergoing peptide bond formation followed by cyclization and decarboxylation to form DPO. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR TI - The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR UR - http://hdl.handle.net/11427/13421 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13421
dc.identifier.vancouvercitationStegmann DE. The investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPR. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13421en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular and Cell Biologyen_ZA
dc.titleThe investiation into the synthesis of 2,5-Diphenyloxazole in Streptomyces polyantibioticus SPRen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2011_stegmann_d.pdf
Size:
2.66 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters