The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study
| dc.contributor.author | Tipping, Brent | |
| dc.contributor.author | Kalula, Sebastiana | |
| dc.contributor.author | Badri, Motasim | |
| dc.date.accessioned | 2017-07-19T12:35:26Z | |
| dc.date.available | 2017-07-19T12:35:26Z | |
| dc.date.issued | 2006 | |
| dc.date.updated | 2016-01-12T09:39:37Z | |
| dc.description.abstract | Objective. To determine the burden and risk factors for adverse drug events (ADEs) in older patients. Design. A prospective cross-sectional study. Methods. Patients (65 years and older) presenting to the tertiary Emergency Unit of Groote Schuur Hospital, Cape Town, between February and May 2005, were assessed for wellestablished ADEs, as defined by the South African Medicines Formulary. Logistic regression models were fitted to determine drugs and other factors associated with the likelihood of developing ADEs. Results. ADEs were identified in 104 of the 517 (20%) presentations. The most frequently involved drug classes were cardiovascular (34%), anticoagulant (27%), analgesic (19%) and antidiabetic (9%). Patients who developed ADEs were more likely to have five or more prescription drugs (p < 0.0001), more than three clinical problems (p = 0.001), require admission (p = 0.04), and report compliance with medication (p = 0.02) than those who did not. Drugs shown to independently confer increased risk of ADEs were angiotensin-converting enzyme inhibitors (RR = 2.6, 95% CI: 1.3 - 5.2, p = 0.009), non-steroidal anti-inflammatory drugs (RR = 4.1, 95% CI: 2.1 - 8.0, p < 0.0001) and warfarin (RR = 3.1, 95% CI: 1.6 - 6.3, p = 0.0014). Conclusion. ADEs contribute significantly to the burden of elderly care in the Emergency Unit. In a setting such as ours, increased pill burden and certain drug classes are likely to result in increased risk of ADEs in the older population group. | |
| dc.identifier | http://dx.doi.org/10.7196/SAMJ.1359 | |
| dc.identifier.apacitation | Tipping, B., Kalula, S., & Badri, M. (2006). The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24774 | en_ZA |
| dc.identifier.chicagocitation | Tipping, Brent, Sebastiana Kalula, and Motasim Badri "The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study." <i>South African Medical Journal</i> (2006) http://hdl.handle.net/11427/24774 | en_ZA |
| dc.identifier.citation | Tipping, B., Kalula, S., & Badri, M. (2006). The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study. South African Medical Journal, 96(12), 1255. | |
| dc.identifier.ris | TY - Journal Article AU - Tipping, Brent AU - Kalula, Sebastiana AU - Badri, Motasim AB - Objective. To determine the burden and risk factors for adverse drug events (ADEs) in older patients. Design. A prospective cross-sectional study. Methods. Patients (65 years and older) presenting to the tertiary Emergency Unit of Groote Schuur Hospital, Cape Town, between February and May 2005, were assessed for wellestablished ADEs, as defined by the South African Medicines Formulary. Logistic regression models were fitted to determine drugs and other factors associated with the likelihood of developing ADEs. Results. ADEs were identified in 104 of the 517 (20%) presentations. The most frequently involved drug classes were cardiovascular (34%), anticoagulant (27%), analgesic (19%) and antidiabetic (9%). Patients who developed ADEs were more likely to have five or more prescription drugs (p < 0.0001), more than three clinical problems (p = 0.001), require admission (p = 0.04), and report compliance with medication (p = 0.02) than those who did not. Drugs shown to independently confer increased risk of ADEs were angiotensin-converting enzyme inhibitors (RR = 2.6, 95% CI: 1.3 - 5.2, p = 0.009), non-steroidal anti-inflammatory drugs (RR = 4.1, 95% CI: 2.1 - 8.0, p < 0.0001) and warfarin (RR = 3.1, 95% CI: 1.6 - 6.3, p = 0.0014). Conclusion. ADEs contribute significantly to the burden of elderly care in the Emergency Unit. In a setting such as ours, increased pill burden and certain drug classes are likely to result in increased risk of ADEs in the older population group. DA - 2006 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study TI - The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study UR - http://hdl.handle.net/11427/24774 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/24774 | |
| dc.identifier.vancouvercitation | Tipping B, Kalula S, Badri M. The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study. South African Medical Journal. 2006; http://hdl.handle.net/11427/24774. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | South African Medical Journal | |
| dc.source.uri | http://www.samj.org.za/index.php/samj | |
| dc.subject.other | Risk factors | |
| dc.subject.other | Older patients | |
| dc.subject.other | Burden | |
| dc.subject.other | Adverse drug effects | |
| dc.title | The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study | |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |