High prevalence of metabolic syndrome in patients with SLE in the Western Cape
| dc.contributor.advisor | Hodkinson, Bridget | |
| dc.contributor.author | Nkabane, Avela Ntombenkosi | |
| dc.date.accessioned | 2021-09-15T11:51:53Z | |
| dc.date.available | 2021-09-15T11:51:53Z | |
| dc.date.issued | 2021 | |
| dc.date.updated | 2021-09-15T00:47:26Z | |
| dc.description.abstract | INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. METHODS: A cross-sectional study of recent onset (<5 years disease duration) patients with SLE meeting the SLICC SLE classification criteria. The MetS was defined by Joint Interim Statement criteria. Clinical and demographic data and a Functional Assessment of Chronic Illness Therapy score and the 36-Item Short-Form Healthy Survey were completed. RESULTS: Of 75 patients, the mean age was 37.1 (11.7) years, disease duration was 30.8 (23.6) months, 65 (86.7%) were female, 68.0% were of mixed ethnic ancestry and 29.3% were Black Africans. The mean SLEDAI score was 0.9 (1.6). The prevalence of MetS was 40.0%, and age and body mass index were the only significant features associated with MetS (p = 0.003 and 0.001 respectively). Increased waist circumference (WC) was the most frequently observed feature, present in 92.9% of MetS patients. Patients with an elevated WC were 32.5 times more likely to have MetS. CONCLUSION: This study shows a high prevalence of MetS amongst South Africans with recently diagnosed SLE. This calls for aggressive strategies to reduce the prevalence of Mets and atherosclerotic cardiovascular disease. Waist circumference is a useful and costeffective screening tool to identify SLE patients at risk of MetS. | |
| dc.identifier.apacitation | Nkabane, A. N. (2021). <i>High prevalence of metabolic syndrome in patients with SLE in the Western Cape</i>. (). ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/33915 | en_ZA |
| dc.identifier.chicagocitation | Nkabane, Avela Ntombenkosi. <i>"High prevalence of metabolic syndrome in patients with SLE in the Western Cape."</i> ., ,Faculty of Health Sciences ,Department of Medicine, 2021. http://hdl.handle.net/11427/33915 | en_ZA |
| dc.identifier.citation | Nkabane, A.N. 2021. High prevalence of metabolic syndrome in patients with SLE in the Western Cape. . ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/33915 | en_ZA |
| dc.identifier.ris | TY - Master Thesis AU - Nkabane, Avela Ntombenkosi AB - INTRODUCTION: Patients with systemic lupus erythematosus (SLE) are at increased risk of the metabolic syndrome (MetS) and its complications. In the absence of published studies from sub-Saharan Africa, we investigated the prevalence and associations of the MetS amongst recent-onset SLE patients. METHODS: A cross-sectional study of recent onset (<5 years disease duration) patients with SLE meeting the SLICC SLE classification criteria. The MetS was defined by Joint Interim Statement criteria. Clinical and demographic data and a Functional Assessment of Chronic Illness Therapy score and the 36-Item Short-Form Healthy Survey were completed. RESULTS: Of 75 patients, the mean age was 37.1 (11.7) years, disease duration was 30.8 (23.6) months, 65 (86.7%) were female, 68.0% were of mixed ethnic ancestry and 29.3% were Black Africans. The mean SLEDAI score was 0.9 (1.6). The prevalence of MetS was 40.0%, and age and body mass index were the only significant features associated with MetS (p = 0.003 and 0.001 respectively). Increased waist circumference (WC) was the most frequently observed feature, present in 92.9% of MetS patients. Patients with an elevated WC were 32.5 times more likely to have MetS. CONCLUSION: This study shows a high prevalence of MetS amongst South Africans with recently diagnosed SLE. This calls for aggressive strategies to reduce the prevalence of Mets and atherosclerotic cardiovascular disease. Waist circumference is a useful and costeffective screening tool to identify SLE patients at risk of MetS. DA - 2021_ DB - OpenUCT DP - University of Cape Town KW - Systemic Lupus Erythematosus KW - Metabolic Syndrome KW - Waist Circumference KW - Africa LK - https://open.uct.ac.za PY - 2021 T1 - High prevalence of metabolic syndrome in patients with SLE in the Western Cape TI - High prevalence of metabolic syndrome in patients with SLE in the Western Cape UR - http://hdl.handle.net/11427/33915 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/33915 | |
| dc.identifier.vancouvercitation | Nkabane AN. High prevalence of metabolic syndrome in patients with SLE in the Western Cape. []. ,Faculty of Health Sciences ,Department of Medicine, 2021 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/33915 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Medicine | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | Systemic Lupus Erythematosus | |
| dc.subject | Metabolic Syndrome | |
| dc.subject | Waist Circumference | |
| dc.subject | Africa | |
| dc.title | High prevalence of metabolic syndrome in patients with SLE in the Western Cape | |
| dc.type | Master Thesis | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |