Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region

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dc.contributor.advisorSaid-Hartley, Mariam Qonita
dc.contributor.authorvan Rensburg, Juan Janse
dc.date.accessioned2025-02-19T12:49:34Z
dc.date.available2025-02-19T12:49:34Z
dc.date.issued2024
dc.date.updated2025-02-19T12:45:24Z
dc.description.abstractBackground: Tuberculosis (TB) and the Human Immunodeficiency Virus (HIV) are a major burden on the health of the people in the Western Cape with approximately 56 000 new cases of TB diagnosed in 2018 and 16 287 incident cases of HIV during the same period. CT-guided lung biopsy is a limited resource primarily used for diagnosing suspected cancer. TB is occasionally diagnosed on samples obtained by CT-guided lung biopsy. Objectives: To quantify the burden of TB on the CT-guided lung biopsy (CTLB) service at Groote Schuur Hospital (GSH). Secondary aims include summarising the diagnoses observed in an HIV-positive subset and comparison of diagnostic performance of different methods for TB diagnosis on biopsy samples. Method: A retrospective review of results from 406 consecutive CTLB performed at a tertiary hospital in the Western Cape during 2018 and 2019. Results: The mean age of subjects was 61 years, and the male to female ratio 1.1:1. A total of 40 specimens (9.9%) had confirmed tuberculosis, 264 (65%) had malignancy, and 3 had concurrent TB and malignancy. Conclusion: This study confirmed a high yield of TB among CTLB specimens as expected in a TB-prevalent region. There was also a higher proportion of TB and of non-TB non-malignant causes of lung nodules and masses in the HIV-positive subset as compared to HIV negative subjects.
dc.identifier.apacitationvan Rensburg, J. J. (2024). <i>Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region</i>. (). University of Cape Town ,Faculty of Health Sciences ,Division of Radiology. Retrieved from http://hdl.handle.net/11427/40988en_ZA
dc.identifier.chicagocitationvan Rensburg, Juan Janse. <i>"Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region."</i> ., University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2024. http://hdl.handle.net/11427/40988en_ZA
dc.identifier.citationvan Rensburg, J.J. 2024. Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region. . University of Cape Town ,Faculty of Health Sciences ,Division of Radiology. http://hdl.handle.net/11427/40988en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - van Rensburg, Juan Janse AB - Background: Tuberculosis (TB) and the Human Immunodeficiency Virus (HIV) are a major burden on the health of the people in the Western Cape with approximately 56 000 new cases of TB diagnosed in 2018 and 16 287 incident cases of HIV during the same period. CT-guided lung biopsy is a limited resource primarily used for diagnosing suspected cancer. TB is occasionally diagnosed on samples obtained by CT-guided lung biopsy. Objectives: To quantify the burden of TB on the CT-guided lung biopsy (CTLB) service at Groote Schuur Hospital (GSH). Secondary aims include summarising the diagnoses observed in an HIV-positive subset and comparison of diagnostic performance of different methods for TB diagnosis on biopsy samples. Method: A retrospective review of results from 406 consecutive CTLB performed at a tertiary hospital in the Western Cape during 2018 and 2019. Results: The mean age of subjects was 61 years, and the male to female ratio 1.1:1. A total of 40 specimens (9.9%) had confirmed tuberculosis, 264 (65%) had malignancy, and 3 had concurrent TB and malignancy. Conclusion: This study confirmed a high yield of TB among CTLB specimens as expected in a TB-prevalent region. There was also a higher proportion of TB and of non-TB non-malignant causes of lung nodules and masses in the HIV-positive subset as compared to HIV negative subjects. DA - 2024 DB - OpenUCT DP - University of Cape Town KW - CT-guided lung biopsy KW - TB KW - HIV LK - https://open.uct.ac.za PB - University of Cape Town PY - 2024 T1 - Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region TI - Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region UR - http://hdl.handle.net/11427/40988 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/40988
dc.identifier.vancouvercitationvan Rensburg JJ. Diagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region. []. University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2024 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/40988en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDivision of Radiology
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectCT-guided lung biopsy
dc.subjectTB
dc.subjectHIV
dc.titleDiagnostic outcomes of CT-guided lung biopsy in an HIV and TB co-infection prevalent region
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMMed
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