Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization

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dc.contributor.authorRademeyer, Ceciliaen_ZA
dc.contributor.authorKorber, Betteen_ZA
dc.contributor.authorSeaman, Michael Sen_ZA
dc.contributor.authorGiorgi, Elena Een_ZA
dc.contributor.authorThebus, Ruwayhidaen_ZA
dc.contributor.authorRobles, Alexanderen_ZA
dc.contributor.authorSheward, Daniel Jen_ZA
dc.contributor.authorWagh, Kshitijen_ZA
dc.contributor.authorGarrity, Jettaen_ZA
dc.contributor.authorCarey, Brittany Ren_ZA
dc.contributor.authorGao, Hongmeien_ZA
dc.contributor.authorGreene, Kelli Men_ZA
dc.contributor.authorTang, Hailien_ZA
dc.contributor.authorBandawe, Gama Pen_ZA
dc.contributor.authorMarais, Jinny Cen_ZA
dc.contributor.authorDiphoko, Thabo Een_ZA
dc.contributor.authorHraber, Peteren_ZA
dc.contributor.authorTumba, Nancyen_ZA
dc.contributor.authorMoore, Penny Len_ZA
dc.contributor.authorGray, Glenda Een_ZA
dc.contributor.authorKublin, Jamesen_ZA
dc.contributor.authorMcElrath, M Julianaen_ZA
dc.contributor.authorVermeulen, Marionen_ZA
dc.contributor.authorMiddelkoop, Kerenen_ZA
dc.contributor.authorBekker, Linda-Gailen_ZA
dc.contributor.authorHoelscher, Michaelen_ZA
dc.contributor.authorMaboko, Leonarden_ZA
dc.contributor.authorMakhema, Josephen_ZA
dc.contributor.authorRobb, Merlin Len_ZA
dc.contributor.authorKarim, Salim Abdoolen_ZA
dc.contributor.authorKarim, Quarraisha Abdoolen_ZA
dc.contributor.authorKim, Jerome Hen_ZA
dc.contributor.authorHahn, Beatrice Hen_ZA
dc.contributor.authorGao, Fengen_ZA
dc.contributor.authorSwanstrom, Ronalden_ZA
dc.contributor.authorMorris, Lynnen_ZA
dc.contributor.authorMontefiori, David Cen_ZA
dc.contributor.authorWilliamson, Carolynen_ZA
dc.date.accessioned2016-10-31T07:34:49Z
dc.date.available2016-10-31T07:34:49Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary: Vaccine and passive immunization prophylactic trials that rely on antibody-mediated protection are planned for HIV-1 clade C epidemic regions of southern Africa, which have amongst the highest HIV-1 incidences globally. This includes a phase 2b trial of passively administered monoclonal antibody, VRC01; as well as a phase 3 trial using the clade C modified version of the partially efficacious RV144 vaccine. The extraordinary diversity of HIV-1 poses a major obstacle to these interventions, and our study aimed to determine the implications of viral diversity on antibody recognition. Investigations using our panel of very early viruses augment current knowledge of vulnerable targets on transmitted viruses for vaccine design and passive immunization studies. Evidence of antigenic drift with viruses becoming more resistant over time suggests that these prevention modalities will need to be updated over time and that combinations of antibodies will be necessary to achieve coverage in passive immunization studies. We further show that it may be more difficult to obtain protection in the genetically diverse clade C epidemic compared to RV144 where the epidemic is less diverse, although it should be noted that the correlates of infection risk are yet to be defined in the clade C setting.en_ZA
dc.identifier.apacitationRademeyer, C., Korber, B., Seaman, M. S., Giorgi, E. E., Thebus, R., Robles, A., ... Williamson, C. (2016). Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization. <i>PLoS One</i>, http://hdl.handle.net/11427/22341en_ZA
dc.identifier.chicagocitationRademeyer, Cecilia, Bette Korber, Michael S Seaman, Elena E Giorgi, Ruwayhida Thebus, Alexander Robles, Daniel J Sheward, et al "Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/22341en_ZA
dc.identifier.citationRademeyer, Cecilia, Bette Korber, Michael S. Seaman, Elena E. Giorgi, Ruwayhida Thebus, Alexander Robles, Daniel J. Sheward et al. "Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization." PLoS Pathog 12, no. 7 (2016): e1005742. doi:10.1371/journal.ppat.1005742en_ZA
dc.identifier.ris TY - Journal Article AU - Rademeyer, Cecilia AU - Korber, Bette AU - Seaman, Michael S AU - Giorgi, Elena E AU - Thebus, Ruwayhida AU - Robles, Alexander AU - Sheward, Daniel J AU - Wagh, Kshitij AU - Garrity, Jetta AU - Carey, Brittany R AU - Gao, Hongmei AU - Greene, Kelli M AU - Tang, Haili AU - Bandawe, Gama P AU - Marais, Jinny C AU - Diphoko, Thabo E AU - Hraber, Peter AU - Tumba, Nancy AU - Moore, Penny L AU - Gray, Glenda E AU - Kublin, James AU - McElrath, M Juliana AU - Vermeulen, Marion AU - Middelkoop, Keren AU - Bekker, Linda-Gail AU - Hoelscher, Michael AU - Maboko, Leonard AU - Makhema, Joseph AU - Robb, Merlin L AU - Karim, Salim Abdool AU - Karim, Quarraisha Abdool AU - Kim, Jerome H AU - Hahn, Beatrice H AU - Gao, Feng AU - Swanstrom, Ronald AU - Morris, Lynn AU - Montefiori, David C AU - Williamson, Carolyn AB - Author Summary: Vaccine and passive immunization prophylactic trials that rely on antibody-mediated protection are planned for HIV-1 clade C epidemic regions of southern Africa, which have amongst the highest HIV-1 incidences globally. This includes a phase 2b trial of passively administered monoclonal antibody, VRC01; as well as a phase 3 trial using the clade C modified version of the partially efficacious RV144 vaccine. The extraordinary diversity of HIV-1 poses a major obstacle to these interventions, and our study aimed to determine the implications of viral diversity on antibody recognition. Investigations using our panel of very early viruses augment current knowledge of vulnerable targets on transmitted viruses for vaccine design and passive immunization studies. Evidence of antigenic drift with viruses becoming more resistant over time suggests that these prevention modalities will need to be updated over time and that combinations of antibodies will be necessary to achieve coverage in passive immunization studies. We further show that it may be more difficult to obtain protection in the genetically diverse clade C epidemic compared to RV144 where the epidemic is less diverse, although it should be noted that the correlates of infection risk are yet to be defined in the clade C setting. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005742 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization TI - Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization UR - http://hdl.handle.net/11427/22341 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005742en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22341
dc.identifier.vancouvercitationRademeyer C, Korber B, Seaman MS, Giorgi EE, Thebus R, Robles A, et al. Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization. PLoS One. 2016; http://hdl.handle.net/11427/22341.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherAntibodiesen_ZA
dc.subject.otherViral vaccinesen_ZA
dc.subject.otherVaccinesen_ZA
dc.subject.otherViral transmission and infectionen_ZA
dc.subject.otherAntibody responseen_ZA
dc.subject.otherSequence analysisen_ZA
dc.subject.otherPhylogenetic analysisen_ZA
dc.titleFeatures of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunizationen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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