The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming

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dc.contributor.authorPrescott, Susan L
dc.contributor.authorLarcombe, Danica-Lea
dc.contributor.authorLogan, Alan C
dc.contributor.authorWest, Christina
dc.contributor.authorBurks, Wesley
dc.contributor.authorCaraballo, Luis
dc.contributor.authorSchoeman, Johan
dc.contributor.authorEtten, Eddie Van
dc.contributor.authorHorwitz, Pierre
dc.contributor.authorKozyrskyj, Anita
dc.contributor.authorCampbell, Dianne E
dc.date.accessioned2021-10-08T07:22:56Z
dc.date.available2021-10-08T07:22:56Z
dc.date.issued2017
dc.description.abstractSkin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. As our primary interface with the external environment, the biodiversity of skin habitats is heavily influenced by the biodiversity of the ecosystems in which we reside. Thus, factors which alter the establishment and health of the skin microbiome have the potential to predispose to not only cutaneous disease, but also other inflammatory non-communicable diseases (NCDs). Indeed, disturbances of the stratum corneum have been noted in allergic diseases (eczema and food allergy), psoriasis, rosacea, acne vulgaris and with the skin aging process. The built environment, global biodiversity losses and declining nature relatedness are contributing to erosion of diversity at a micro-ecological level, including our own microbial habitats. This emphasises the importance of ecological perspectives in overcoming the factors that drive dysbiosis and the risk of inflammatory diseases across the life course.
dc.identifier.apacitationPrescott, S. L., Larcombe, D., Logan, A. C., West, C., Burks, W., Caraballo, L., ... Campbell, D. E. (2017). The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. <i>World Allergy Organization Journal</i>, 10(1), 174 - 177. http://hdl.handle.net/11427/35033en_ZA
dc.identifier.chicagocitationPrescott, Susan L, Danica-Lea Larcombe, Alan C Logan, Christina West, Wesley Burks, Luis Caraballo, Johan Schoeman, et al "The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming." <i>World Allergy Organization Journal</i> 10, 1. (2017): 174 - 177. http://hdl.handle.net/11427/35033en_ZA
dc.identifier.citationPrescott, S.L., Larcombe, D., Logan, A.C., West, C., Burks, W., Caraballo, L., Schoeman, J. & Etten, E.V. et al. 2017. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. <i>World Allergy Organization Journal.</i> 10(1):174 - 177. http://hdl.handle.net/11427/35033en_ZA
dc.identifier.issn1939-4551
dc.identifier.ris TY - Journal Article AU - Prescott, Susan L AU - Larcombe, Danica-Lea AU - Logan, Alan C AU - West, Christina AU - Burks, Wesley AU - Caraballo, Luis AU - Schoeman, Johan AU - Etten, Eddie Van AU - Horwitz, Pierre AU - Kozyrskyj, Anita AU - Campbell, Dianne E AB - Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. As our primary interface with the external environment, the biodiversity of skin habitats is heavily influenced by the biodiversity of the ecosystems in which we reside. Thus, factors which alter the establishment and health of the skin microbiome have the potential to predispose to not only cutaneous disease, but also other inflammatory non-communicable diseases (NCDs). Indeed, disturbances of the stratum corneum have been noted in allergic diseases (eczema and food allergy), psoriasis, rosacea, acne vulgaris and with the skin aging process. The built environment, global biodiversity losses and declining nature relatedness are contributing to erosion of diversity at a micro-ecological level, including our own microbial habitats. This emphasises the importance of ecological perspectives in overcoming the factors that drive dysbiosis and the risk of inflammatory diseases across the life course. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - World Allergy Organization Journal LK - https://open.uct.ac.za PY - 2017 SM - 1939-4551 T1 - The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming TI - The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming UR - http://hdl.handle.net/11427/35033 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35033
dc.identifier.vancouvercitationPrescott SL, Larcombe D, Logan AC, West C, Burks W, Caraballo L, et al. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Organization Journal. 2017;10(1):174 - 177. http://hdl.handle.net/11427/35033.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Paediatric Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceWorld Allergy Organization Journal
dc.source.journalissue1
dc.source.journalvolume10
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s40413-017-0160-5
dc.subject.otherAllergy
dc.subject.otherAntibiotics
dc.subject.otherBiodiversity
dc.subject.otherCaesarean section
dc.subject.otherColonisation
dc.subject.otherCytokines
dc.subject.otherDOHaD
dc.subject.otherEcosystems
dc.subject.otherInflammation
dc.subject.otherMicrobiome
dc.subject.otherMicrobiota
dc.subject.otherNCDs
dc.subject.otherPregnancy
dc.subject.otherPrevention
dc.subject.otherSkin
dc.titleThe skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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