Blood cultures in sick children

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dc.contributor.authorLochan, Harsha
dc.contributor.authorBamford, Colleen
dc.contributor.authorEley, Brian
dc.date.accessioned2021-10-08T07:18:02Z
dc.date.available2021-10-08T07:18:02Z
dc.date.issued2013
dc.description.abstractBACKGROUND: Blood cultures (BCs) are frequently performed in sick children. A recent audit of BCs among adult patients documented high rates of contamination by coagulase-negative staphylococci (CoNS). OBJECTIVES: To describe BC contamination rates and common pathogenic organisms causing bloodstream infection in children at a tertiary- level children's hospital. METHODS: BC results for children admitted to Red Cross War Memorial Children's Hospital from 2008 to 2012 were extracted from the National Health Laboratory Service database. Pathogenic and non-pathogenic (contaminated) growth on BCs in children <1 year of age and >1 year of age, were analysed. Data analysis was performed using Epi Info version 3.5.1. RESULTS: A total of 47 677 BCs were performed in the 5-year period. The proportion of contaminated specimens ranged between 5.9% and 7.2% per year (p=0.4). CoNS was the predominant isolate in 53.8% of all contaminated BCs. Children <1 year of age experienced higher contamination rates than children >1 year of age (8.7% v. 4.7%; relative risk 1.84; 95% confidence interval (CI) 1.71 - 1.97). Pathogenic organisms were isolated in 6.2% (95% CI 6.0 - 6.4) of all BC specimens. Among Gram-positive organisms, the proportion of Streptococcus pneumoniae isolates declined from 14.3% to 4.7% (p<0.00001), while there was a significant increase in Gram-negative organisms (51.8% - 57.9%; p=0.04) over the 5-year period. Klebsiella pneumoniae, the predominant Enterobacteriaceae isolated, decreased from 45.8% to 31.7% (p=0.004). CONCLUSION: This study identified unacceptably high BC contamination rates, emphasising the importance of collecting BC specimens under sterile conditions.
dc.identifier.apacitationLochan, H., Bamford, C., & Eley, B. (2013). Blood cultures in sick children. <i>South African Medical Journal</i>, 103(12), 918 - 177. http://hdl.handle.net/11427/34891en_ZA
dc.identifier.chicagocitationLochan, Harsha, Colleen Bamford, and Brian Eley "Blood cultures in sick children." <i>South African Medical Journal</i> 103, 12. (2013): 918 - 177. http://hdl.handle.net/11427/34891en_ZA
dc.identifier.citationLochan, H., Bamford, C. & Eley, B. 2013. Blood cultures in sick children. <i>South African Medical Journal.</i> 103(12):918 - 177. http://hdl.handle.net/11427/34891en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Lochan, Harsha AU - Bamford, Colleen AU - Eley, Brian AB - BACKGROUND: Blood cultures (BCs) are frequently performed in sick children. A recent audit of BCs among adult patients documented high rates of contamination by coagulase-negative staphylococci (CoNS). OBJECTIVES: To describe BC contamination rates and common pathogenic organisms causing bloodstream infection in children at a tertiary- level children's hospital. METHODS: BC results for children admitted to Red Cross War Memorial Children's Hospital from 2008 to 2012 were extracted from the National Health Laboratory Service database. Pathogenic and non-pathogenic (contaminated) growth on BCs in children <1 year of age and >1 year of age, were analysed. Data analysis was performed using Epi Info version 3.5.1. RESULTS: A total of 47 677 BCs were performed in the 5-year period. The proportion of contaminated specimens ranged between 5.9% and 7.2% per year (p=0.4). CoNS was the predominant isolate in 53.8% of all contaminated BCs. Children <1 year of age experienced higher contamination rates than children >1 year of age (8.7% v. 4.7%; relative risk 1.84; 95% confidence interval (CI) 1.71 - 1.97). Pathogenic organisms were isolated in 6.2% (95% CI 6.0 - 6.4) of all BC specimens. Among Gram-positive organisms, the proportion of Streptococcus pneumoniae isolates declined from 14.3% to 4.7% (p<0.00001), while there was a significant increase in Gram-negative organisms (51.8% - 57.9%; p=0.04) over the 5-year period. Klebsiella pneumoniae, the predominant Enterobacteriaceae isolated, decreased from 45.8% to 31.7% (p=0.004). CONCLUSION: This study identified unacceptably high BC contamination rates, emphasising the importance of collecting BC specimens under sterile conditions. DA - 2013 DB - OpenUCT DP - University of Cape Town IS - 12 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 2013 SM - 0038-2469 T1 - Blood cultures in sick children TI - Blood cultures in sick children UR - http://hdl.handle.net/11427/34891 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34891
dc.identifier.vancouvercitationLochan H, Bamford C, Eley B. Blood cultures in sick children. South African Medical Journal. 2013;103(12):918 - 177. http://hdl.handle.net/11427/34891.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue12
dc.source.journalvolume103
dc.source.pagination918 - 177
dc.source.urihttps://dx.doi.org/10.7196/SAMJ.6979
dc.subject.otherAge Factors
dc.subject.otherBacteremia
dc.subject.otherBacteria
dc.subject.otherBacteriological Techniques
dc.subject.otherBlood Specimen Collection
dc.subject.otherChild
dc.subject.otherChild, Preschool
dc.subject.otherEquipment Contamination
dc.subject.otherFemale
dc.subject.otherHumans
dc.subject.otherInfant
dc.subject.otherMale
dc.subject.otherRetrospective Studies
dc.subject.otherRisk Factors
dc.subject.otherSouth Africa
dc.titleBlood cultures in sick children
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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