HIV type 1 subtype C gag and nef diversity in Southern Africa.

dc.contributor.authorBredell, Helba
dc.contributor.authorMartin, Darren P
dc.contributor.authorVan Harmelen Joanne
dc.contributor.authorVarsani, Arvind
dc.contributor.authorSheppard, Haynes W
dc.contributor.authorDonovan, R
dc.contributor.authorGray, C
dc.contributor.authorHIVNET028 Study Team
dc.contributor.authorWilliamson, C
dc.date.accessioned2016-07-15T12:29:54Z
dc.date.available2016-07-15T12:29:54Z
dc.date.issued2007
dc.date.updated2016-07-15T12:25:56Z
dc.description.abstractSeveral HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess the degree of southern African HIV-1 diversity that will confront these vaccines. Whereas reasonable phylogenetic evidence exists for geographical clustering of subtype C gag and nef sequences from various other parts of the world, there is little evidence of similar population founder effects in the southern African epidemic. The entire breadth of subtype C diversity is represented in the southern African genes suggesting there may be no advantage in producing region- or country-specific subtype C vaccines. We do not, however, find much evidence of intersubtype recombination in the Southern African genes, implying that the likelihood of vaccine failure due to the emergence of intersubtype recombinants is probably low.en_ZA
dc.identifierhttp://dx.doi.org/10.1089/aid.2006.0232
dc.identifier.apacitationBredell, H., Martin, D. P., , Varsani, A., Sheppard, H. W., Donovan, R., ... Williamson, C. (2007). HIV type 1 subtype C gag and nef diversity in Southern Africa. <i>AIDS Research and Human Retroviruses</i>, http://hdl.handle.net/11427/20379en_ZA
dc.identifier.chicagocitationBredell, Helba, Darren P Martin, , Arvind Varsani, Haynes W Sheppard, R Donovan, C Gray, , and C Williamson "HIV type 1 subtype C gag and nef diversity in Southern Africa." <i>AIDS Research and Human Retroviruses</i> (2007) http://hdl.handle.net/11427/20379en_ZA
dc.identifier.citationBredell, H., Martin, D. P., Van Harmelen, J., Varsani, A., Sheppard, H. W., Donovan, R., ... & Williamson, C. (2007). HIV type 1 subtype C gag and nef diversity in Southern Africa. AIDS research and human retroviruses, 23(3), 477-481.en_ZA
dc.identifier.issn0889-2229en_ZA
dc.identifier.ris TY - Journal Article AU - Bredell, Helba AU - Martin, Darren P AU - Van Harmelen Joanne AU - Varsani, Arvind AU - Sheppard, Haynes W AU - Donovan, R AU - Gray, C AU - HIVNET028 Study Team AU - Williamson, C AB - Several HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess the degree of southern African HIV-1 diversity that will confront these vaccines. Whereas reasonable phylogenetic evidence exists for geographical clustering of subtype C gag and nef sequences from various other parts of the world, there is little evidence of similar population founder effects in the southern African epidemic. The entire breadth of subtype C diversity is represented in the southern African genes suggesting there may be no advantage in producing region- or country-specific subtype C vaccines. We do not, however, find much evidence of intersubtype recombination in the Southern African genes, implying that the likelihood of vaccine failure due to the emergence of intersubtype recombinants is probably low. DA - 2007 DB - OpenUCT DP - University of Cape Town J1 - AIDS Research and Human Retroviruses LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 SM - 0889-2229 T1 - HIV type 1 subtype C gag and nef diversity in Southern Africa TI - HIV type 1 subtype C gag and nef diversity in Southern Africa UR - http://hdl.handle.net/11427/20379 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20379
dc.identifier.urihttp://online.liebertpub.com/doi/abs/10.1089/aid.2006.0232
dc.identifier.vancouvercitationBredell H, Martin DP, , Varsani A, Sheppard HW, Donovan R, et al. HIV type 1 subtype C gag and nef diversity in Southern Africa. AIDS Research and Human Retroviruses. 2007; http://hdl.handle.net/11427/20379.en_ZA
dc.languageengen_ZA
dc.publisherMary Ann Lieberten_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceAIDS Research and Human Retrovirusesen_ZA
dc.source.urihttp://online.liebertpub.com/doi/abs/10.1089/aid.2006.0232
dc.subject.otherHIV/AIDS: Type 1
dc.subject.otherSubtype C
dc.subject.otherGag
dc.subject.otherSouthern Africa
dc.titleHIV type 1 subtype C gag and nef diversity in Southern Africa.en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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