Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa
| dc.contributor.advisor | de Lacy, Ronalda | |
| dc.contributor.author | Ndhlovu, Lesego | |
| dc.date.accessioned | 2024-05-30T09:41:07Z | |
| dc.date.available | 2024-05-30T09:41:07Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2024-05-28T08:39:29Z | |
| dc.description.abstract | Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications. | |
| dc.identifier.apacitation | Ndhlovu, L. (2023). <i>Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa</i>. (). ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/39758 | en_ZA |
| dc.identifier.chicagocitation | Ndhlovu, Lesego. <i>"Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa."</i> ., ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2023. http://hdl.handle.net/11427/39758 | en_ZA |
| dc.identifier.citation | Ndhlovu, L. 2023. Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa. . ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/39758 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Ndhlovu, Lesego AB - Background: Nutrition in chronic liver disease is an important marker of post- liver transplant outcomes in children and is monitored judiciously pre-transplantation. There is a paucity of data on post-transplant nutritional outcomes, particularly in the developing world setting. Aim: To describe the nutritional outcomes of children following liver transplantation. Methods: A retrospective study of patient's receiving post-transplant care at Red Cross War Memorial Children's Hospital in Cape Town, South Africa from 2004 – 2019. Results: 31 children were included in the analysis. Pre-transplant prevalence of stunting was 57,1%, with 32,1% of children severely stunted. At 24 months post-transplant 65,5% of children were stunted, with 44,8% severely stunted. Overweight and obesity prevalence was 0% pretransplant, and 32,2% and 27,6% at 12- and 24-months post-transplant respectively. Biliary atresia was the diagnosis in 89,5% of children with stunting at 24 months vs in 50% of children without stunting at 24 months post-transplant (p = 0.03). Mean pre-transplant albumin was lower in children with stunting at 24 months post-transplant than in children without stunting (26,7 vs 29,6 g/L respectively; p < 0,001). Age at transplant was lower in children with stunting at 24 months post-transplant vs children without stunting (40,7 versus 91,5 months; p < 0.001). Twenty-one (67,7%) children developed hypertension post-transplant. Conclusion: Stunting, hypertension and overweight/obesity are highly prevalent post paediatric liver transplantation. Lower pre-transplant albumin, younger age at transplant, and diagnosis of biliary atresia were associated with post-transplant stunting. Post-transplant growth monitoring seems prudent to prevent the development of overnutrition and associated metabolic complications. DA - 2023 DB - OpenUCT DP - University of Cape Town KW - Paediatric Gastroenterology LK - https://open.uct.ac.za PY - 2023 T1 - Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa TI - Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa UR - http://hdl.handle.net/11427/39758 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/39758 | |
| dc.identifier.vancouvercitation | Ndhlovu L. Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa. []. ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/39758 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Paediatrics and Child Health | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | Paediatric Gastroenterology | |
| dc.title | Describing The Nutritional Outcomes Following Paediatric Liver Transplantation At A Tertiary Hospital In South Africa | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MPhil |