Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution
| dc.contributor.author | Catenacci, Laura | |
| dc.contributor.author | Vicatos, Alexios I. | |
| dc.contributor.author | Sorrenti, Milena | |
| dc.contributor.author | Edmonds-Smith, Cesarina | |
| dc.contributor.author | Bonferoni, Maria Cristina | |
| dc.contributor.author | Caira, Mino R. | |
| dc.date.accessioned | 2024-04-29T10:29:04Z | |
| dc.date.available | 2024-04-29T10:29:04Z | |
| dc.date.issued | 2023-02-07 | |
| dc.date.updated | 2023-02-24T14:09:22Z | |
| dc.description.abstract | Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for medicinal applications. The potent antioxidant pterostilbene (PTB) is a case in point. The aim of this study was to use a series of modified water-soluble cyclodextrins (CDs), namely, hydroxypropyl β-CD (HPβCD), dimethylated β-CD (DIMEB), randomly methylated β-CD (RAMEB), and sulfobutyl ether β-CD sodium salt (SBECD) to prepare inclusion complexes of PTB via various solid, semi-solid, and solution-based treatments. Putative CD–PTB products generated by solid-state co-grinding, kneading, irradiation with microwaves, and the evaporative treatment of CD–PTB solutions were considered to have potential for future applications. Primary analytical methods for examining CD–PTB products included differential scanning calorimetry and Fourier transform infrared spectroscopy to detect the occurrence of binary complex formation. Phase solubility analysis was used to probe CD–PTB complexation in an aqueous solution. Complexation was evident in both the solid-state and in solution. Complex association constants (K1:1) in an aqueous solution spanned the approximate range of 15,000 to 55,000 M−1 ; the values increased with the CDs in the order HPβCD < DIMEB < RAMEB < SBECD. Significant PTB solubility enhancement factors were recorded at 100 mM CD concentrations, the most accurately determined values being in the range 700-fold to 1250-fold. | |
| dc.identifier | doi: 10.3390/ph16020247 | |
| dc.identifier.apacitation | Catenacci, L., Vicatos, Alexios I., Sorrenti, M., Edmonds-Smith, C., Bonferoni, M. C., & Caira, Mino R. (2023). Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution. 16(2), 247. http://hdl.handle.net/11427/39474 | en_ZA |
| dc.identifier.chicagocitation | Catenacci, Laura, Alexios I. Vicatos, Milena Sorrenti, Cesarina Edmonds-Smith, Maria Cristina Bonferoni, and Mino R. Caira "Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution." 16, 2. (2023): 247. http://hdl.handle.net/11427/39474 | en_ZA |
| dc.identifier.citation | Catenacci, L., Vicatos, Alexios I., Sorrenti, M., Edmonds-Smith, C., Bonferoni, M.C. & Caira, Mino R. 2023. Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution. 16(2):247. http://hdl.handle.net/11427/39474 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Catenacci, Laura AU - Vicatos, Alexios I. AU - Sorrenti, Milena AU - Edmonds-Smith, Cesarina AU - Bonferoni, Maria Cristina AU - Caira, Mino R. AB - Inadequate aqueous solubilities of bioactive compounds hinder their ability to be developed for medicinal applications. The potent antioxidant pterostilbene (PTB) is a case in point. The aim of this study was to use a series of modified water-soluble cyclodextrins (CDs), namely, hydroxypropyl β-CD (HPβCD), dimethylated β-CD (DIMEB), randomly methylated β-CD (RAMEB), and sulfobutyl ether β-CD sodium salt (SBECD) to prepare inclusion complexes of PTB via various solid, semi-solid, and solution-based treatments. Putative CD–PTB products generated by solid-state co-grinding, kneading, irradiation with microwaves, and the evaporative treatment of CD–PTB solutions were considered to have potential for future applications. Primary analytical methods for examining CD–PTB products included differential scanning calorimetry and Fourier transform infrared spectroscopy to detect the occurrence of binary complex formation. Phase solubility analysis was used to probe CD–PTB complexation in an aqueous solution. Complexation was evident in both the solid-state and in solution. Complex association constants (K<sub>1:1</sub>) in an aqueous solution spanned the approximate range of 15,000 to 55,000 M<sup>−1</sup>; the values increased with the CDs in the order HPβCD < DIMEB < RAMEB < SBECD. Significant PTB solubility enhancement factors were recorded at 100 mM CD concentrations, the most accurately determined values being in the range 700-fold to 1250-fold. DA - 2023-02-07 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PY - 2023 T1 - Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution TI - Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution UR - http://hdl.handle.net/11427/39474 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/39474 | |
| dc.identifier.uri | https://doi.org/10.3390/ph16020247 | |
| dc.identifier.vancouvercitation | Catenacci L, Vicatos Alexios I, Sorrenti M, Edmonds-Smith C, Bonferoni MC, Caira Mino R. Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution. 2023;16(2):247. http://hdl.handle.net/11427/39474. | en_ZA |
| dc.publisher | Multidisciplinary Digital Publishing Institute | |
| dc.source.journalissue | 2 | |
| dc.source.journalvolume | 16 | |
| dc.source.pagination | 247 | |
| dc.title | Complexation between the Antioxidant Pterostilbene and Derivatized Cyclodextrins in the Solid State and in Aqueous Solution | |
| dc.type | Journal Article |