Uric acid metabolism in the Dalmatian coach hound

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dc.contributor.advisorHarley, Eric Hen_ZA
dc.contributor.authorBriggs, Oliver Martinen_ZA
dc.date.accessioned2018-02-05T12:35:47Z
dc.date.available2018-02-05T12:35:47Z
dc.date.issued1982en_ZA
dc.description.abstractThe Dalmatian coach hound, when compared to other dog breeds, exhibits three characteristic abnormalities of uric acid metabolism, namely hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic cystitis and deafness are also found in the Dalmatian and whether there is any causal relationship with the uric acid disorder is unknown. In terms of the quantity of uric acid excreted, the Dalmatian dog resembles man more closely than the non-Dalmatian. On the other hand, in its high renal urate clearance, this breed of dogs differs from man, whose renal clearance values are lower and therefore closer to those of the non-Dalmatian. In this respect the Dalmatian resembles man affected with the inborn renal urate transport defect of renal hypouricaemia. The significance of uric acid metabolism in the Dalmatian has attracted many investigators in search of the underlying metabolic defect(s). Study of the Dalmatian may also be relevant to the understanding of disorders of purine metabolism in man for example hyperuricosuria, uric acid urolithiasis and hereditary renal hypouricaemia.en_ZA
dc.identifier.apacitationBriggs, O. M. (1982). <i>Uric acid metabolism in the Dalmatian coach hound</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology. Retrieved from http://hdl.handle.net/11427/27257en_ZA
dc.identifier.chicagocitationBriggs, Oliver Martin. <i>"Uric acid metabolism in the Dalmatian coach hound."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 1982. http://hdl.handle.net/11427/27257en_ZA
dc.identifier.citationBriggs, O. 1982. Uric acid metabolism in the Dalmatian coach hound. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Briggs, Oliver Martin AB - The Dalmatian coach hound, when compared to other dog breeds, exhibits three characteristic abnormalities of uric acid metabolism, namely hyperuricaemia, hyperuricosuria and increased renal uric acid clearance. These properties are associated with hypoallantoinaemia and hypoallantoinuria. A result of these abnormalities is a high incidence of urate urolithiasis in this breed. Other diseases such as recurrent dermatitis, chronic cystitis and deafness are also found in the Dalmatian and whether there is any causal relationship with the uric acid disorder is unknown. In terms of the quantity of uric acid excreted, the Dalmatian dog resembles man more closely than the non-Dalmatian. On the other hand, in its high renal urate clearance, this breed of dogs differs from man, whose renal clearance values are lower and therefore closer to those of the non-Dalmatian. In this respect the Dalmatian resembles man affected with the inborn renal urate transport defect of renal hypouricaemia. The significance of uric acid metabolism in the Dalmatian has attracted many investigators in search of the underlying metabolic defect(s). Study of the Dalmatian may also be relevant to the understanding of disorders of purine metabolism in man for example hyperuricosuria, uric acid urolithiasis and hereditary renal hypouricaemia. DA - 1982 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1982 T1 - Uric acid metabolism in the Dalmatian coach hound TI - Uric acid metabolism in the Dalmatian coach hound UR - http://hdl.handle.net/11427/27257 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27257
dc.identifier.vancouvercitationBriggs OM. Uric acid metabolism in the Dalmatian coach hound. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Chemical Pathology, 1982 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27257en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Chemical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemical Pathologyen_ZA
dc.titleUric acid metabolism in the Dalmatian coach hounden_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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