Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique

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dc.contributor.authorMaueia, Cremildo
dc.contributor.authorMurahwa, Alltalents
dc.contributor.authorManjate, Alice
dc.contributor.authorAndersson, Soren
dc.contributor.authorSacarlal, Jahit
dc.contributor.authorKenga, Darlene
dc.contributor.authorMussá, Tufária
dc.contributor.authorWilliamson, Anna-Lise
dc.date.accessioned2022-04-06T09:08:51Z
dc.date.available2022-04-06T09:08:51Z
dc.date.issued2021-12-23
dc.date.updated2022-01-20T15:24:37Z
dc.description.abstractBackground: Human papillomavirus (HPV) infection is now a well-established cause of cervical cancer and other anogenital cancers. An association between human immunodeficiency virus (HIV) infection and higher HPV incidence and prevalence are commonly reported. This study was conducted to demonstrate HPV prevalence, genotypes and its characteristics, according to the HIV status in women from Maputo in Mozambique. Methods: A total of 233 participants with ages ranging from fourteen to forty-five were included. Cervical samples were collected, DNA extracted, and HPV genotyping was performed using the HPV Direct Flow CHIP Kit. Results: In total, 177 HIV-negative and 56 HIV-positive women were included in the analysis. The overall HPV prevalence was 63% and was significantly higher among HIV-positive women (79% versus 58% among HIV-negative women; <i>p</i> = 0.005). The prevalence of multiple HPV type infections was 32%. High-risk HPV types 52, 68, 35, 18 and 16 were the most frequent. A higher proportion of HIV-positive women had multiple HPV types compared with HIV-negative women. Conclusions: This study demonstrated a high prevalence of HPV in the study cohort. HIV-positive women were identified as having the highest HPV prevalence and infection with multiple HPV types across all ages. High-risk genotypes were the most commonly found.en_US
dc.identifierdoi: 10.3390/v14010024
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.citationViruses 14 (1): 24 (2022)
dc.identifier.urihttp://hdl.handle.net/11427/36283
dc.language.isoenen_US
dc.publisher.departmentDepartment of Pathologyen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceVirusesen_US
dc.source.journalissue1en_US
dc.source.journalvolume14en_US
dc.source.pagination24en_US
dc.source.urihttps://www.mdpi.com/journal/viruses
dc.subjecthuman papillomavirusen_US
dc.subjecthuman immunodeficiency virusen_US
dc.subjectwomenen_US
dc.titleIdentification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambiqueen_US
dc.typeJournal Articleen_US
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