Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa

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dc.contributor.advisorDavies, Mary-Annen_ZA
dc.contributor.authorKampiire, Leatitiaen_ZA
dc.date.accessioned2015-01-02T09:17:54Z
dc.date.available2015-01-02T09:17:54Z
dc.date.issued2013en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractAccording to the Joint United Nations Programme on HIV/AIDS (UNAIDS) South Africa 2010 Country Progress report, 81% of South African children in need of antiretroviral therapy (ART) were receiving treatment which is a 20% increment in treatment access from 2008 to 2009. With increase in access to treatment, understanding drug tolerability, safety and durability is important especially among children whose drug options are limited due to few drugs being available in suitable formulations and the need for refrigeration of some drugs. While there are many paediatric studies on ART durability in the developed world, data from the developing world are limited. There is therefore a need to understand the drug-specific probability of and reasons for drug stops or changes among children initiated on ART in South Africa. This knowledge could help in optimisation of use of firstline ART in order to maximise time on first-line therapy and thereby maintain simplicity of programs (program-level benefit) and save alternative drugs for situations of toxicity and virological failure (individual benefit).en_ZA
dc.identifier.apacitationKampiire, L. (2013). <i>Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/11003en_ZA
dc.identifier.chicagocitationKampiire, Leatitia. <i>"Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2013. http://hdl.handle.net/11427/11003en_ZA
dc.identifier.citationKampiire, L. 2013. Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kampiire, Leatitia AB - According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) South Africa 2010 Country Progress report, 81% of South African children in need of antiretroviral therapy (ART) were receiving treatment which is a 20% increment in treatment access from 2008 to 2009. With increase in access to treatment, understanding drug tolerability, safety and durability is important especially among children whose drug options are limited due to few drugs being available in suitable formulations and the need for refrigeration of some drugs. While there are many paediatric studies on ART durability in the developed world, data from the developing world are limited. There is therefore a need to understand the drug-specific probability of and reasons for drug stops or changes among children initiated on ART in South Africa. This knowledge could help in optimisation of use of firstline ART in order to maximise time on first-line therapy and thereby maintain simplicity of programs (program-level benefit) and save alternative drugs for situations of toxicity and virological failure (individual benefit). DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa TI - Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa UR - http://hdl.handle.net/11427/11003 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11003
dc.identifier.vancouvercitationKampiire L. Substitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africa. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11003en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleSubstitutions to initial anteretroviral therapy due to toxicity or contraindication among children in South Africaen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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