Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis

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dc.contributor.authorNdjoubi, Kadidiatou O
dc.contributor.authorSharma, Rajan
dc.contributor.authorBadmus, Jelili A
dc.contributor.authorJacobs, Ayesha
dc.contributor.authorJordaan, Audrey
dc.contributor.authorMarnewick, Jeanine
dc.contributor.authorWarner, Digby F
dc.contributor.authorHussein, Ahmed A
dc.date.accessioned2021-10-18T08:42:31Z
dc.date.available2021-10-18T08:42:31Z
dc.date.issued2021-01-19
dc.date.updated2021-01-22T15:47:33Z
dc.description.abstractMedicinal plants of the Plectranthus genus (Lamiaceae) are well known for their ethnomedicinal applications. Plectranthus madagascariensis, which is native to South Africa, is traditionally used in the treatment of respiratory conditions, scabies, and cutaneous wounds. The phytochemical studies of P. madagascariensis led to the isolation of five known royleanone abietanes, namely, 6β,7α-dihydroxyroyleanone (1), 7α-acetoxy-6β-hydroxyroyleanone (2), horminone (3), coleon U quinone (4), and carnosolon (5). The relative configuration of compound 2 was established by X-ray analysis. Compounds 1–4 showed antimycobacterial activity (Minimum inhibitory concentration for 90% inhibition, MIC90 = 5.61–179.60 μM) against Mycobacterium tuberculosis H37Rv. Compound 4 and 5 showed comparable toxicity (Concentration for 50% inhibition, IC50 98.49 μM and 79.77 μM) to tamoxifen (IC50 22.00 μg/mL) against HaCaT cells. Compounds 1–5 showed antioxidant activity through single-electron transfer (SET) and/or hydrogen-atom transfer (HAT) with compound 5 being the most active antioxidant agent. Compounds 3 and 5 were isolated for the first time from P. madagascariensis. The observed results suggest P. madagascariensis as an important ethnomedicinal plant and as a promising source of diterpenoids with potential use in the treatment of tuberculosis and psoriasis.en_US
dc.identifierdoi: 10.3390/plants10010175
dc.identifier.apacitationNdjoubi, K. O., Sharma, R., Badmus, J. A., Jacobs, A., Jordaan, A., Marnewick, J., ... Hussein, A. A. (2021). Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis. <i>Plants</i>, 10(1), http://hdl.handle.net/11427/35261en_ZA
dc.identifier.chicagocitationNdjoubi, Kadidiatou O, Rajan Sharma, Jelili A Badmus, Ayesha Jacobs, Audrey Jordaan, Jeanine Marnewick, Digby F Warner, and Ahmed A Hussein "Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis." <i>Plants</i> 10, 1. (2021) http://hdl.handle.net/11427/35261en_ZA
dc.identifier.citationNdjoubi, K.O., Sharma, R., Badmus, J.A., Jacobs, A., Jordaan, A., Marnewick, J., Warner, D.F. & Hussein, A.A. et al. 2021. Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis. <i>Plants.</i> 10(1) http://hdl.handle.net/11427/35261en_ZA
dc.identifier.risTY - Journal Article AU - Ndjoubi, Kadidiatou O AU - Sharma, Rajan AU - Badmus, Jelili A AU - Jacobs, Ayesha AU - Jordaan, Audrey AU - Marnewick, Jeanine AU - Warner, Digby F AU - Hussein, Ahmed A AB - Medicinal plants of the Plectranthus genus (Lamiaceae) are well known for their ethnomedicinal applications. Plectranthus madagascariensis, which is native to South Africa, is traditionally used in the treatment of respiratory conditions, scabies, and cutaneous wounds. The phytochemical studies of P. madagascariensis led to the isolation of five known royleanone abietanes, namely, 6β,7α-dihydroxyroyleanone (1), 7α-acetoxy-6β-hydroxyroyleanone (2), horminone (3), coleon U quinone (4), and carnosolon (5). The relative configuration of compound 2 was established by X-ray analysis. Compounds 1–4 showed antimycobacterial activity (Minimum inhibitory concentration for 90% inhibition, MIC90 = 5.61–179.60 μM) against Mycobacterium tuberculosis H37Rv. Compound 4 and 5 showed comparable toxicity (Concentration for 50% inhibition, IC50 98.49 μM and 79.77 μM) to tamoxifen (IC50 22.00 μg/mL) against HaCaT cells. Compounds 1–5 showed antioxidant activity through single-electron transfer (SET) and/or hydrogen-atom transfer (HAT) with compound 5 being the most active antioxidant agent. Compounds 3 and 5 were isolated for the first time from P. madagascariensis. The observed results suggest P. madagascariensis as an important ethnomedicinal plant and as a promising source of diterpenoids with potential use in the treatment of tuberculosis and psoriasis. DA - 2021-01-19 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Plants KW - Plectranthus madagascariensis KW - abietane diterpenoids LK - https://open.uct.ac.za PY - 2021 T1 - Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis TI - Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis UR - http://hdl.handle.net/11427/35261 ER -en_ZA
dc.identifier.urihttps://doi.org/10.3390/plants10010175
dc.identifier.urihttp://hdl.handle.net/11427/35261
dc.identifier.vancouvercitationNdjoubi KO, Sharma R, Badmus JA, Jacobs A, Jordaan A, Marnewick J, et al. Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensis. Plants. 2021;10(1) http://hdl.handle.net/11427/35261.en_ZA
dc.language.isoenen_US
dc.publisher.departmentDivision of Medical Microbiology
dc.publisher.facultyFaculty of Health Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.rights.urihttps://www.mdpi.com/journal/plants
dc.sourcePlantsen_US
dc.source.journalissue1en_US
dc.source.journalvolume10en_US
dc.source.urihttps://www.mdpi.com/journal/plants
dc.subjectPlectranthus madagascariensis
dc.subjectabietane diterpenoids
dc.subjecttuberculosis
dc.subjectantioxidant
dc.subjectcytotoxicity
dc.titleAntimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from Plectranthus madagascariensisen_US
dc.typeJournal Articleen_US
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