The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

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dc.contributor.authorPeres, Jadeen_ZA
dc.contributor.authorPrince, Sharonen_ZA
dc.date.accessioned2015-11-27T09:32:39Z
dc.date.available2015-11-27T09:32:39Z
dc.date.issued2013en_ZA
dc.description.abstractThe T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.en_ZA
dc.identifier.apacitationPeres, J., & Prince, S. (2013). The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion. <i>Molecular Cancer</i>, http://hdl.handle.net/11427/15392en_ZA
dc.identifier.chicagocitationPeres, Jade, and Sharon Prince "The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion." <i>Molecular Cancer</i> (2013) http://hdl.handle.net/11427/15392en_ZA
dc.identifier.citationPeres, J., & Prince, S. (2013). The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion. Mol Cancer, 12(1), 117-4598.en_ZA
dc.identifier.ris TY - Journal Article AU - Peres, Jade AU - Prince, Sharon AB - The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion. DA - 2013 DB - OpenUCT DO - 10.1186/1476-4598-12-117 DP - University of Cape Town J1 - Molecular Cancer LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion TI - The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion UR - http://hdl.handle.net/11427/15392 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15392
dc.identifier.urihttp://dx.doi.org/10.1186/1476-4598-12-117
dc.identifier.vancouvercitationPeres J, Prince S. The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion. Molecular Cancer. 2013; http://hdl.handle.net/11427/15392.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holderPeres and Prince; licensee BioMed Central Ltd. 2013en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceMolecular Canceren_ZA
dc.source.urihttp://molecular-cancer.biomedcentral.com/en_ZA
dc.subject.otherTBX3en_ZA
dc.subject.otherMelanomaen_ZA
dc.subject.otherMigrationen_ZA
dc.subject.otherInvasionen_ZA
dc.titleThe T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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