Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart

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dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.advisorSack, Michael Nen_ZA
dc.contributor.authorMakaula, Siyanda S Sen_ZA
dc.date.accessioned2014-07-28T11:02:07Z
dc.date.available2014-07-28T11:02:07Z
dc.date.issued2000en_ZA
dc.descriptionBibliographical references.
dc.description.abstractCardiac ischaemic preconditioning (IPC) describes a biological phenomenon whereby a short ischaemic stimulus confers protection to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme will enable us to augment tissue tolerance against cell death. Ischaemic preconditioning is poorly understood, however, certain metabolic events and activation intracellular signalling events are known to trigger this cardioprotection. The purpose of this study was to investigate the metabolic and intracellular signalling events which occur during ischaemic preconditioning and their effects on improvement of contractile recovery following an ischaemia/reperfusion insult.en_ZA
dc.identifier.apacitationMakaula, S. S. S. (2000). <i>Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT Cape Heart Centre. Retrieved from http://hdl.handle.net/11427/2789en_ZA
dc.identifier.chicagocitationMakaula, Siyanda S S. <i>"Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT Cape Heart Centre, 2000. http://hdl.handle.net/11427/2789en_ZA
dc.identifier.citationMakaula, S. 2000. Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Makaula, Siyanda S S AB - Cardiac ischaemic preconditioning (IPC) describes a biological phenomenon whereby a short ischaemic stimulus confers protection to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme will enable us to augment tissue tolerance against cell death. Ischaemic preconditioning is poorly understood, however, certain metabolic events and activation intracellular signalling events are known to trigger this cardioprotection. The purpose of this study was to investigate the metabolic and intracellular signalling events which occur during ischaemic preconditioning and their effects on improvement of contractile recovery following an ischaemia/reperfusion insult. DA - 2000 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2000 T1 - Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart TI - Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart UR - http://hdl.handle.net/11427/2789 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2789
dc.identifier.vancouvercitationMakaula SSS. Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT Cape Heart Centre, 2000 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2789en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT Cape Heart Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titlePreconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat hearten_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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