The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use
| dc.contributor.author | Donald, Kirsten A M | |
| dc.contributor.author | Fernandez, Anne | |
| dc.contributor.author | Claborn, Kasey | |
| dc.contributor.author | Kuo, Caroline | |
| dc.contributor.author | Koen, Nastassja | |
| dc.contributor.author | Zar, Heather | |
| dc.contributor.author | Stein, Dan J | |
| dc.date.accessioned | 2017-07-14T08:36:25Z | |
| dc.date.available | 2017-07-14T08:36:25Z | |
| dc.date.issued | 2017-05-08 | |
| dc.date.updated | 2017-05-08T18:04:08Z | |
| dc.description.abstract | Background: There is growing evidence of the negative impact of alcohol on morbidity and mortality of individuals living with HIV but limited evidence of in utero efects of HIV and alcohol on exposure on infants. Methods: We conducted a population-based birth cohort study (N = 667 mother-infant dyads) in South Africa to investigate whether maternal alcohol use and HIV afected gestational outcomes. Descriptive data analysis was conducted for all variables using frequency distributions, measures of central tendency, and estimates of variance. Hierarchical multiple regression was conducted to determine whether maternal alcohol use, maternal HIV status and other risk factors (socioeconomic status, smoking, depression) predicted infant outcomes. Results: Our results showed severity of recent alcohol use and lifetime alcohol use predicted low birth weight. Similarly lifetime alcohol use predicted shorter infant length, smaller head length, smaller head circumference, and early gestational age. However, HIV status was not a signifcant predictor of gestational outcomes. Conclusions: The unexpected fnding that maternal HIV status did not predict any of the gestational outcomes may be due to high rates of ART usage among HIV-infected mothers. The potentially negative efects of HIV on gestational outcomes may have been attenuated by improved maternal health due to high coverage of antiretroviral treatment in South Africa. Interventions are needed to reduce alcohol consumption among pregnant mothers and to support healthy growth and psychosocial development of infants. | |
| dc.identifier.apacitation | Donald, K. A. M., Fernandez, A., Claborn, K., Kuo, C., Koen, N., Zar, H., & Stein, D. J. (2017). The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use. <i>AIDS Research and Therapy</i>, http://hdl.handle.net/11427/24736 | en_ZA |
| dc.identifier.chicagocitation | Donald, Kirsten A M, Anne Fernandez, Kasey Claborn, Caroline Kuo, Nastassja Koen, Heather Zar, and Dan J Stein "The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use." <i>AIDS Research and Therapy</i> (2017) http://hdl.handle.net/11427/24736 | en_ZA |
| dc.identifier.citation | Donald, K. A., Fernandez, A., Claborn, K., Kuo, C., Koen, N., Zar, H., & Stein, D. J. (2017). The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use. AIDS research and therapy, 14(1), 28. | |
| dc.identifier.ris | TY - Journal Article AU - Donald, Kirsten A M AU - Fernandez, Anne AU - Claborn, Kasey AU - Kuo, Caroline AU - Koen, Nastassja AU - Zar, Heather AU - Stein, Dan J AB - Background: There is growing evidence of the negative impact of alcohol on morbidity and mortality of individuals living with HIV but limited evidence of in utero efects of HIV and alcohol on exposure on infants. Methods: We conducted a population-based birth cohort study (N = 667 mother-infant dyads) in South Africa to investigate whether maternal alcohol use and HIV afected gestational outcomes. Descriptive data analysis was conducted for all variables using frequency distributions, measures of central tendency, and estimates of variance. Hierarchical multiple regression was conducted to determine whether maternal alcohol use, maternal HIV status and other risk factors (socioeconomic status, smoking, depression) predicted infant outcomes. Results: Our results showed severity of recent alcohol use and lifetime alcohol use predicted low birth weight. Similarly lifetime alcohol use predicted shorter infant length, smaller head length, smaller head circumference, and early gestational age. However, HIV status was not a signifcant predictor of gestational outcomes. Conclusions: The unexpected fnding that maternal HIV status did not predict any of the gestational outcomes may be due to high rates of ART usage among HIV-infected mothers. The potentially negative efects of HIV on gestational outcomes may have been attenuated by improved maternal health due to high coverage of antiretroviral treatment in South Africa. Interventions are needed to reduce alcohol consumption among pregnant mothers and to support healthy growth and psychosocial development of infants. DA - 2017-05-08 DB - OpenUCT DO - 10.1186/s12981-017-0153-z DP - University of Cape Town J1 - AIDS Research and Therapy LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use TI - The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use UR - http://hdl.handle.net/11427/24736 ER - | en_ZA |
| dc.identifier.uri | http://dx.doi.org/10.1186/s12981-017-0153-z | |
| dc.identifier.uri | http://hdl.handle.net/11427/24736 | |
| dc.identifier.vancouvercitation | Donald KAM, Fernandez A, Claborn K, Kuo C, Koen N, Zar H, et al. The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use. AIDS Research and Therapy. 2017; http://hdl.handle.net/11427/24736. | en_ZA |
| dc.language.iso | en | |
| dc.publisher | BioMed Central | |
| dc.publisher.department | Department of Psychiatry and Mental Health | en_ZA |
| dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License | |
| dc.rights.holder | The Author(s) | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.source | AIDS Research and Therapy | |
| dc.source.uri | https://aidsrestherapy.biomedcentral.com/ | |
| dc.subject.other | Gestational outcomes | |
| dc.subject.other | Alcohol | |
| dc.subject.other | HIV | |
| dc.subject.other | South Africa | |
| dc.subject.other | Pregnancy | |
| dc.title | The developmental effects of HIV and alcohol: a comparison of gestational outcomes among babies from South African communities with high prevalence of HIV and alcohol use | |
| dc.type | Journal Article | |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |