Transition metal complexes of tetracyclines

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dc.contributor.advisorPay, M Hen_ZA
dc.contributor.advisorFazakerley, G Ven_ZA
dc.contributor.authorCunningham, David Grahamen_ZA
dc.date.accessioned2016-03-14T07:22:47Z
dc.date.available2016-03-14T07:22:47Z
dc.date.issued1973en_ZA
dc.description.abstractForty-one transition metals were studied to observe their complexing properties with the tetracyclines. Four metals were found to form sufficiently strong complexes with the tetracyclines to provide a basis for a rapid, reliable method of assaying the potency of the tetracycline products used in medicine today. Microbiological methods take twenty hours to perform; spectrophotometric methods may be completed within one hour. Twenty-eight of the transition metals showed evidence of complex formation with the tetracyclines; not all of these complexes were found to be suitable for the spectrophotometric assay of the tetracyclines, however. The ligand-metal ratios of some of the transition metal-tetracycline complexes were determined under specified conditions using Job's method. In the concentration range for ligand and metal (3 x 10⁻⁵ M), the 1 : 1 complexes appeared to predominate. Attempts were made to identify the binding sites of the metal ions on the tetracycline molecules, using infra-red spectrophotometry, but the results were inconclusive. The stability constant of one of the transition metal-tetracycline complexes was determined by a potentiometric method. Using this method, the result for the titanium-tetracycline complex was β₁= 3,4 x 10¹⁵ M⁻¹.en_ZA
dc.identifier.apacitationCunningham, D. G. (1973). <i>Transition metal complexes of tetracyclines</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/17731en_ZA
dc.identifier.chicagocitationCunningham, David Graham. <i>"Transition metal complexes of tetracyclines."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1973. http://hdl.handle.net/11427/17731en_ZA
dc.identifier.citationCunningham, D. 1973. Transition metal complexes of tetracyclines. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Cunningham, David Graham AB - Forty-one transition metals were studied to observe their complexing properties with the tetracyclines. Four metals were found to form sufficiently strong complexes with the tetracyclines to provide a basis for a rapid, reliable method of assaying the potency of the tetracycline products used in medicine today. Microbiological methods take twenty hours to perform; spectrophotometric methods may be completed within one hour. Twenty-eight of the transition metals showed evidence of complex formation with the tetracyclines; not all of these complexes were found to be suitable for the spectrophotometric assay of the tetracyclines, however. The ligand-metal ratios of some of the transition metal-tetracycline complexes were determined under specified conditions using Job's method. In the concentration range for ligand and metal (3 x 10⁻⁵ M), the 1 : 1 complexes appeared to predominate. Attempts were made to identify the binding sites of the metal ions on the tetracycline molecules, using infra-red spectrophotometry, but the results were inconclusive. The stability constant of one of the transition metal-tetracycline complexes was determined by a potentiometric method. Using this method, the result for the titanium-tetracycline complex was β₁= 3,4 x 10¹⁵ M⁻¹. DA - 1973 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1973 T1 - Transition metal complexes of tetracyclines TI - Transition metal complexes of tetracyclines UR - http://hdl.handle.net/11427/17731 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17731
dc.identifier.vancouvercitationCunningham DG. Transition metal complexes of tetracyclines. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1973 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/17731en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleTransition metal complexes of tetracyclinesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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