Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study

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dc.contributor.authorPapavarnavas, Nectarios S
dc.contributor.authorManning, Kathryn
dc.contributor.authorConrad, Fahd
dc.contributor.authorGovender, Milah
dc.contributor.authorMaartens, Gary
dc.date.accessioned2017-06-23T09:08:41Z
dc.date.available2017-06-23T09:08:41Z
dc.date.issued2017-04-21
dc.date.updated2017-04-21T18:07:07Z
dc.description.abstractBackground: There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used. Methods: A retrospective cohort study was conducted of HCWs attending a referral hospital’s Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias. Results: Two hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5–0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3–5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3–26.9]). Conclusion: We identifed factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up.
dc.identifier.apacitationPapavarnavas, N. S., Manning, K., Conrad, F., Govender, M., & Maartens, G. (2017). Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study. <i>AIDS Research and Therapy</i>, http://hdl.handle.net/11427/24616en_ZA
dc.identifier.chicagocitationPapavarnavas, Nectarios S, Kathryn Manning, Fahd Conrad, Milah Govender, and Gary Maartens "Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study." <i>AIDS Research and Therapy</i> (2017) http://hdl.handle.net/11427/24616en_ZA
dc.identifier.citationPapavarnavas, N. S., Manning, K., Conrad, F., Govender, M., & Maartens, G. (2017). Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study. AIDS research and therapy, 14(1), 23.
dc.identifier.ris TY - Journal Article AU - Papavarnavas, Nectarios S AU - Manning, Kathryn AU - Conrad, Fahd AU - Govender, Milah AU - Maartens, Gary AB - Background: There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used. Methods: A retrospective cohort study was conducted of HCWs attending a referral hospital’s Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias. Results: Two hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5–0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3–5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3–26.9]). Conclusion: We identifed factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up. DA - 2017-04-21 DB - OpenUCT DO - 10.1186/s12981-017-0149-8 DP - University of Cape Town J1 - AIDS Research and Therapy LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study TI - Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study UR - http://hdl.handle.net/11427/24616 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12981-017-0149-8
dc.identifier.urihttp://hdl.handle.net/11427/24616
dc.identifier.vancouvercitationPapavarnavas NS, Manning K, Conrad F, Govender M, Maartens G. Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study. AIDS Research and Therapy. 2017; http://hdl.handle.net/11427/24616.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s)
dc.sourceAIDS Research and Therapy
dc.source.urihttps://aidsrestherapy.biomedcentral.com/
dc.subject.otherLoss to follow-up
dc.subject.otherPost exposure prophylaxis
dc.subject.otherHealth care workers
dc.subject.otherHIV
dc.titleFactors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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