Is air pollution a risk factor for rheumatoid arthritis?

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dc.contributor.authorEssouma, Mickaelen_ZA
dc.contributor.authorNoubiap, Jeanen_ZA
dc.date.accessioned2015-12-07T08:52:10Z
dc.date.available2015-12-07T08:52:10Z
dc.date.issued2015en_ZA
dc.description.abstractRheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case-control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution's effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis.en_ZA
dc.identifier.apacitationEssouma, M., & Noubiap, J. (2015). Is air pollution a risk factor for rheumatoid arthritis?. <i>Journal of Inflammation</i>, http://hdl.handle.net/11427/15649en_ZA
dc.identifier.chicagocitationEssouma, Mickael, and Jean Noubiap "Is air pollution a risk factor for rheumatoid arthritis?." <i>Journal of Inflammation</i> (2015) http://hdl.handle.net/11427/15649en_ZA
dc.identifier.citationEssouma, M., & Noubiap, J. J. (2015). Is air pollution a risk factor for rheumatoid arthritis?. Journal of Inflammation, 12(1), 48.en_ZA
dc.identifier.ris TY - Journal Article AU - Essouma, Mickael AU - Noubiap, Jean AB - Rheumatoid arthritis is a chronic inflammatory debilitating disease triggered by a complex interaction involving genetic and environmental factors. Active smoking and occupational exposures such as silica increase its risk, suggesting that initial inflammation and generation of rheumatoid arthritis-related autoantibodies in the lungs may precede the clinical disease. This hypothesis paved the way to epidemiological studies investigating air pollution as a potential determinant of rheumatoid arthritis. Studies designed for epidemiology of rheumatoid arthritis found a link between traffic, a surrogate of air pollution, and this disease. Furthermore, a small case-control study recently found an association between wood smoke exposure and anticyclic citrullinated protein/peptide antibody in sera of patients presenting wood-smoke-related chronic obstructive pulmonary disease. However, reports addressing impact of specific pollutants on rheumatoid arthritis incidence and severity across populations are somewhat conflicting. In addition to the link reported between other systemic autoimmune rheumatic diseases and particulate matters/gaseous pollutants, experimental observation of exacerbated rheumatoid arthritis incidence and severity in mice models of collagen-induced arthritis after diesel exhaust particles exposure as well as hypovitaminosis D-related autoimmunity can help understand the role of air pollution in rheumatoid arthritis. All these considerations highlight the necessity to extend high quality epidemiological researches investigating different sources of atmospheric pollution across populations and particularly in low-and-middle countries, in order to further explore the biological plausibility of air pollution's effect in the pathogenesis of rheumatoid arthritis. This should be attempted to better inform policies aiming to reduce the burden of rheumatoid arthritis. DA - 2015 DB - OpenUCT DO - 10.1186/s12950-015-0092-1 DP - University of Cape Town J1 - Journal of Inflammation LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Is air pollution a risk factor for rheumatoid arthritis? TI - Is air pollution a risk factor for rheumatoid arthritis? UR - http://hdl.handle.net/11427/15649 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15649
dc.identifier.urihttp://dx.doi.org/10.1186/s12950-015-0092-1
dc.identifier.vancouvercitationEssouma M, Noubiap J. Is air pollution a risk factor for rheumatoid arthritis?. Journal of Inflammation. 2015; http://hdl.handle.net/11427/15649.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Essouma and Noubiap.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceJournal of Inflammationen_ZA
dc.source.urihttp://www.journal-inflammation.com/en_ZA
dc.subject.otherRheumatoid arthritisen_ZA
dc.subject.otherPathogenesisen_ZA
dc.subject.otherEnvironmental risk factorsen_ZA
dc.subject.otherAir pollutionen_ZA
dc.titleIs air pollution a risk factor for rheumatoid arthritis?en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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