The role of human breast milk mucus and mucins in HIV-AIDS

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dc.contributor.advisorMall, Anwar Sulemanen_ZA
dc.contributor.authorMthembu, Yolandaen_ZA
dc.date.accessioned2015-01-10T13:38:33Z
dc.date.available2015-01-10T13:38:33Z
dc.date.issued2012en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractMilk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1.en_ZA
dc.identifier.apacitationMthembu, Y. (2012). <i>The role of human breast milk mucus and mucins in HIV-AIDS</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Surgery. Retrieved from http://hdl.handle.net/11427/11999en_ZA
dc.identifier.chicagocitationMthembu, Yolanda. <i>"The role of human breast milk mucus and mucins in HIV-AIDS."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2012. http://hdl.handle.net/11427/11999en_ZA
dc.identifier.citationMthembu, Y. 2012. The role of human breast milk mucus and mucins in HIV-AIDS. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mthembu, Yolanda AB - Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - The role of human breast milk mucus and mucins in HIV-AIDS TI - The role of human breast milk mucus and mucins in HIV-AIDS UR - http://hdl.handle.net/11427/11999 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11999
dc.identifier.vancouvercitationMthembu Y. The role of human breast milk mucus and mucins in HIV-AIDS. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11999en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Surgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Scienceen_ZA
dc.titleThe role of human breast milk mucus and mucins in HIV-AIDSen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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