The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation

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dc.contributor.authorRuff, Paul
dc.contributor.authorSchlaphoff, Terry
dc.contributor.authordu Toit, Ernette
dc.contributor.authorHeyns, Anthon
dc.date.accessioned2018-02-14T08:11:45Z
dc.date.available2018-02-14T08:11:45Z
dc.date.issued2008
dc.date.updated2016-01-21T03:27:41Z
dc.description.abstractIn 1939 Osgood et al. reported infusing bone marrow into patients with severe aplastic anaemia without any clinical benefit. Rekers and Coulter attempted to reconstitute marrow function in irradiated dogs by marrow infusions. Both failed because of insufficient irradiation to produce immunosuppression necessary for engraftment. In 1957 Donnall Thomas and co-workers showed that marrow can be collected, stored in significant quantities and safely administered. Marrow transplants remained unsuccessful, however, although patients with refractory leukaemia given supralethal irradiation recovered after marrow infusion from identical twins. Allogeneic marrow transplants usually resulted in failed engraftment, or engraftment followed by lethal graft-versus-host disease (GVHD). Further discoveries were the HLA complex and transplantation antigens, and that successful allogeneic engrafting depends upon donor/recipient histocompatibility.
dc.identifier.apacitationRuff, P., Schlaphoff, T., du Toit, E., & Heyns, A. (2008). The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/27567en_ZA
dc.identifier.chicagocitationRuff, Paul, Terry Schlaphoff, Ernette du Toit, and Anthon Heyns "The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation." <i>South African Medical Journal</i> (2008) http://hdl.handle.net/11427/27567en_ZA
dc.identifier.citationRuff, P., Schlaphoff, T., Du Toit, E., & Heyns, A. (2008). The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation. SAMJ: South African Medical Journal, 98(7), 516-518.
dc.identifier.ris TY - Journal Article AU - Ruff, Paul AU - Schlaphoff, Terry AU - du Toit, Ernette AU - Heyns, Anthon AB - In 1939 Osgood et al. reported infusing bone marrow into patients with severe aplastic anaemia without any clinical benefit. Rekers and Coulter attempted to reconstitute marrow function in irradiated dogs by marrow infusions. Both failed because of insufficient irradiation to produce immunosuppression necessary for engraftment. In 1957 Donnall Thomas and co-workers showed that marrow can be collected, stored in significant quantities and safely administered. Marrow transplants remained unsuccessful, however, although patients with refractory leukaemia given supralethal irradiation recovered after marrow infusion from identical twins. Allogeneic marrow transplants usually resulted in failed engraftment, or engraftment followed by lethal graft-versus-host disease (GVHD). Further discoveries were the HLA complex and transplantation antigens, and that successful allogeneic engrafting depends upon donor/recipient histocompatibility. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation TI - The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation UR - http://hdl.handle.net/11427/27567 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27567
dc.identifier.vancouvercitationRuff P, Schlaphoff T, du Toit E, Heyns A. The South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation. South African Medical Journal. 2008; http://hdl.handle.net/11427/27567.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Medical Journal
dc.source.urihttp://www.samj.org.za/index.php/samj
dc.titleThe South African Bone Marrow Registry (SABMR) and allogeneic bone marrow transplantation
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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