Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe

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dc.contributor.authorChin'ombe, Nyashaen_ZA
dc.contributor.authorChavhunduka, Evansen_ZA
dc.contributor.authorMatarira, Hildaen_ZA
dc.date.accessioned2015-10-28T06:45:32Z
dc.date.available2015-10-28T06:45:32Z
dc.date.issued2009en_ZA
dc.description.abstractBACKGROUND:Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer.en_ZA
dc.identifier.apacitationChin'ombe, N., Chavhunduka, E., & Matarira, H. (2009). Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. <i>Infectious Agents and Cancer</i>, http://hdl.handle.net/11427/14422en_ZA
dc.identifier.chicagocitationChin'ombe, Nyasha, Evans Chavhunduka, and Hilda Matarira "Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe." <i>Infectious Agents and Cancer</i> (2009) http://hdl.handle.net/11427/14422en_ZA
dc.identifier.citationChin'ombe, N., Chavhunduka, E., & Matarira, H. T. (2009). Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. Infect Agent Cancer, 4, 15.en_ZA
dc.identifier.ris TY - Journal Article AU - Chin'ombe, Nyasha AU - Chavhunduka, Evans AU - Matarira, Hilda AB - BACKGROUND:Primary hepatocellular carcinoma (PHC) is one of the most common cancers in Zimbabwe. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are suspected to play a major role in causing this cancer. The objective of this study was to determine the seroprevalence of HBV and HCV in PHC at Parirenyatwa Referral Hospital in Zimbabwe. We evaluated the serological markers of the two viruses in patients with PHC using commercially available enzyme-linked immunosorbent kits. RESULTS: Out of the 60 patients with PHC, 48.3% were seropositive for HBV and 20.0% were seropositive for HCV. Co-infection by HCV and HBV was found in 8% of the patients. Only 13.3% of the health controls (blood donors) were positive for HBV. All the controls were negative for HCV. CONCLUSION: The high seropositivity of HBV and HCV in PHC in Zimbabwe suggested that the two viruses were a major cause of the cancer. DA - 2009 DB - OpenUCT DO - 10.1186/1750-9378-4-15 DP - University of Cape Town J1 - Infectious Agents and Cancer LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe TI - Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe UR - http://hdl.handle.net/11427/14422 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14422
dc.identifier.urihttp://dx.doi.org/10.1186/1750-9378-4-15
dc.identifier.vancouvercitationChin'ombe N, Chavhunduka E, Matarira H. Seroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabwe. Infectious Agents and Cancer. 2009; http://hdl.handle.net/11427/14422.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2009 Chin'ombe et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceInfectious Agents and Canceren_ZA
dc.source.urihttp://www.infectagentscancer.comen_ZA
dc.subject.otherPrimary hepatocellular carcinomaen_ZA
dc.subject.otherHepatitis B virusen_ZA
dc.subject.otherHepatitis B virusen_ZA
dc.titleSeroprevalence of HBV and HCV in primary hepatocellular carcinoma patients in Zimbabween_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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