Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children

Simple item page
dc.contributor.authorZhang, Cen_ZA
dc.contributor.authorDenti, Pen_ZA
dc.contributor.authorSimonsson, USHen_ZA
dc.contributor.authorMaartens, Garyen_ZA
dc.contributor.authorKarlsson, MOen_ZA
dc.contributor.authorMcIlleron, Hen_ZA
dc.date.accessioned2015-12-07T08:51:44Z
dc.date.available2015-12-07T08:51:44Z
dc.date.issued2010en_ZA
dc.description.abstractChildren with HIV associated tuberculosis often require co-formulated lopinavir/ritonavir (LPV/RTV)-based antiretroviral treatment with rifampicin-based antitubercular treatment (ATT). Rifampicin (RIF), a potent inducer of drug-metabolizing systems, profoundly reduces the bioavailability of LPV. The aims of this study were to develop an integrated population pharmacokinetic (PK) model describing LPV and RTV PK in children with and without concomitant ATT using two different dosing approaches and to estimate doses of LPV/RTV achieving target exposures during ATT in young children.en_ZA
dc.identifier.apacitationZhang, C., Denti, P., Simonsson, U., Maartens, G., Karlsson, M., & McIlleron, H. (2010). Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children. <i>Journal of the International AIDS Society</i>, http://hdl.handle.net/11427/15647en_ZA
dc.identifier.chicagocitationZhang, C, P Denti, USH Simonsson, Gary Maartens, MO Karlsson, and H McIlleron "Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children." <i>Journal of the International AIDS Society</i> (2010) http://hdl.handle.net/11427/15647en_ZA
dc.identifier.citationZhang, C., Denti, P., Simonsson, U. S. H., Maartens, G., Karlsson, M. O., & McIlleron, H. (2010). Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children. Journal of the International AIDS Society, 13(Suppl 4), O24.en_ZA
dc.identifier.ris TY - Journal Article AU - Zhang, C AU - Denti, P AU - Simonsson, USH AU - Maartens, Gary AU - Karlsson, MO AU - McIlleron, H AB - Children with HIV associated tuberculosis often require co-formulated lopinavir/ritonavir (LPV/RTV)-based antiretroviral treatment with rifampicin-based antitubercular treatment (ATT). Rifampicin (RIF), a potent inducer of drug-metabolizing systems, profoundly reduces the bioavailability of LPV. The aims of this study were to develop an integrated population pharmacokinetic (PK) model describing LPV and RTV PK in children with and without concomitant ATT using two different dosing approaches and to estimate doses of LPV/RTV achieving target exposures during ATT in young children. DA - 2010 DB - OpenUCT DO - 10.1186/1758-2652-13-S4-O24 DP - University of Cape Town J1 - Journal of the International AIDS Society LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children TI - Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children UR - http://hdl.handle.net/11427/15647 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15647
dc.identifier.urihttp://dx.doi.org/10.1186/1758-2652-13-S4-O24
dc.identifier.vancouvercitationZhang C, Denti P, Simonsson U, Maartens G, Karlsson M, McIlleron H. Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children. Journal of the International AIDS Society. 2010; http://hdl.handle.net/11427/15647.en_ZA
dc.language.isoengen_ZA
dc.publisherSpringeren_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2010 Zhang et al; licensee BioMed Central Ltden_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of the International AIDS Societyen_ZA
dc.source.urihttp://www.jiasociety.org/index.php/jiasen_ZA
dc.subject.otherPopulation pharmacokineticsen_ZA
dc.subject.otherlopinaviren_ZA
dc.subject.otherritonaviren_ZA
dc.titlePopulation pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected childrenen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Zhang_Population_pharmacokinetics_2010.pdf
Size:
181.85 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles