Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines

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dc.contributor.advisorRybicki, Eden_ZA
dc.contributor.advisorHitzeroth, Ingaen_ZA
dc.contributor.authorBurger, Marietaen_ZA
dc.date.accessioned2015-02-04T19:14:50Z
dc.date.available2015-02-04T19:14:50Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (leaves 129-146).en_ZA
dc.description.abstractHuman papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of cervical cancer cases worldwide. Two vaccines are available on the market: Gardasil(R), targeted against HPV -16, -18; -6 and -11, and Cervarix(TM), against -16 and -18. Both vaccines are based on the L1 capsid proteins of the types they are targeted to and are efficient, pro- phylactic, typespecific vaccines. However, two problems remain: they do not protect against nonvaccine types, that may cause a significant proportion of cancers specifically in African and HIV- positive populations, and they cannot be used to treat existing infections. We designed eight different chimaeric vaccines.en_ZA
dc.identifier.apacitationBurger, M. (2010). <i>Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/12377en_ZA
dc.identifier.chicagocitationBurger, Marieta. <i>"Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2010. http://hdl.handle.net/11427/12377en_ZA
dc.identifier.citationBurger, M. 2010. Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Burger, Marieta AB - Human papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of cervical cancer cases worldwide. Two vaccines are available on the market: Gardasil(R), targeted against HPV -16, -18; -6 and -11, and Cervarix(TM), against -16 and -18. Both vaccines are based on the L1 capsid proteins of the types they are targeted to and are efficient, pro- phylactic, typespecific vaccines. However, two problems remain: they do not protect against nonvaccine types, that may cause a significant proportion of cancers specifically in African and HIV- positive populations, and they cannot be used to treat existing infections. We designed eight different chimaeric vaccines. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines TI - Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines UR - http://hdl.handle.net/11427/12377 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12377
dc.identifier.vancouvercitationBurger M. Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12377en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular and Cell Biologyen_ZA
dc.titleProduction and immunogenicity of chimaeric human papillomavirus-like particle vaccinesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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